Effects of Child and Maternal Histo-Blood Group Antigen Status on Symptomatic and Asymptomatic Enteric Infections in Early Childhood

Josh M. Colston, Ruthly Francois, Nora Pisanic, Pablo Peñataro Yori, Benjamin J.J. Mccormick, Maribel Paredes Olortegui, Md Amran Gazi, Erling Svensen, Mondar Maruf Moin Ahmed, Esto Mduma, Jie Liu, Eric R. Houpt, Robert Klapheke, Julia W. Schwarz, Robert L. Atmar, Robert E. Black, Margaret N. Kosek

Research output: Contribution to journalArticle

Abstract

Background: Histo-blood group antigens (HBGAs) such as fucosyltransferase (FUT)2 and 3 may act as innate host factors that differentially influence susceptibility of individuals and their offspring to pediatric enteric infections. Methods: In 3 community-based birth cohorts, FUT2 and FUT3 statuses were ascertained for mother-child dyads. Quantitative polymerase chain reaction panels tested 3663 diarrheal and 18 148 asymptomatic stool samples for 29 enteropathogens. Cumulative diarrhea and infection incidence were compared by child (n = 520) and mothers' (n = 519) HBGA status and hazard ratios (HRs) derived for all-cause diarrhea and specific enteropathogens. Results: Children of secretor (FUT2 positive) mothers had a 38% increased adjusted risk of all-cause diarrhea (HR = 1.38; 95% confidence interval (CI), 1.15-1.66) and significantly reduced time to first diarrheal episode. Child FUT2 and FUT3 positivity reduced the risk for all-cause diarrhea by 29% (HR = 0.81; 95% CI, 0.71-0.93) and 27% (HR = 0.83; 95% CI, 0.74-0.92), respectively. Strong associations between HBGAs and pathogen-specific infection and diarrhea were observed, particularly for noroviruses, rotaviruses, enterotoxigenic Escherichia coli, and Campylobacter jejuni/coli. Conclusions: Histo-blood group antigens affect incidence of all-cause diarrhea and enteric infections at magnitudes comparable to many common disease control interventions. Studies measuring impacts of interventions on childhood enteric disease should account for both child and mothers' HBGA status.

Original languageEnglish (US)
Article numberjiz072
Pages (from-to)151-162
Number of pages12
JournalJournal of Infectious Diseases
Volume220
Issue number1
DOIs
StatePublished - Jun 5 2019

Keywords

  • Escherichia coli infections
  • antibodies, bacterial
  • bacterial vaccines
  • colonization factor antigens
  • controlled human infection model
  • diarrhea, prevention and control
  • fimbriae proteins
  • immunization, passive
  • milk proteins, immunology
  • randomized controlled clinical trial

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Colston, J. M., Francois, R., Pisanic, N., Peñataro Yori, P., Mccormick, B. J. J., Olortegui, M. P., Gazi, M. A., Svensen, E., Ahmed, M. M. M., Mduma, E., Liu, J., Houpt, E. R., Klapheke, R., Schwarz, J. W., Atmar, R. L., Black, R. E., & Kosek, M. N. (2019). Effects of Child and Maternal Histo-Blood Group Antigen Status on Symptomatic and Asymptomatic Enteric Infections in Early Childhood. Journal of Infectious Diseases, 220(1), 151-162. [jiz072]. https://doi.org/10.1093/infdis/jiz072