Effects of celecoxib and naproxen on renal function in the elderly

Andrew Whelton, Gerald Schulman, Carl Wallemark, Edward J. Drower, Peter C. Isakson, Kenneth M. Verburg, G. Steven Geis

Research output: Contribution to journalArticlepeer-review

262 Scopus citations


Objective: To compare the effects of celecoxib, a cyclooxygenase 2- specific inhibitor, with the nonspecific cyclooxygenase 1 and 2 inhibitor naproxen on renal function in 29 healthy elderly subjects in a single-blind, randomized, crossover study. Methods: Subjects received either celecoxib, 200 mg twice daily, for 5 days followed by celecoxib, 400 mg twice daily, for the next 5 days, or they received naproxen, 500 mg twice daily, for 10 days. After a 7-day washout, subjects were crossed over to receive the other regimen. Results: After the first dose, the trend was for a greater decrease in glomerular filtration rate with naproxen (-5.31 mL/min per 1.73 m2) compared with celecoxib (-0.86 mL/min per 1.73 m2). The treatment difference became statistically significant on day 6 (-7.53 vs -1.11 mL/min per 1.73 m2 for naproxen and celecoxib, respectively; P=.004). Urinary prostaglandin E2 and 6-keto-prostaglandin F(1α) excretion was significantly reduced from baseline across the treatment interval with both celecoxib and naproxen (P≤.04). There were no significant differences in prostaglandin excretion between these 2 agents (P≥.07). Small, transient decreases (P2 and 6-keto-prostaglandin F(1α) excretion, appear to be similar to those of nonspecific cyclooxygenase inhibitors such as naproxen.

Original languageEnglish (US)
Pages (from-to)1465-1470
Number of pages6
JournalArchives of Internal Medicine
Issue number10
StatePublished - May 22 2000

ASJC Scopus subject areas

  • Internal Medicine


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