Effects of catecholamines on ovarian contractility in the rabbit

Pramuan Virutamasen, Karen H. Wright, Edward E. Wallach

Research output: Contribution to journalArticlepeer-review

Abstract

Ovarian contractility was investigated in vivo anti in vitro anti correlated with time of ovulation in HCG-treated rabbits. Effects of catecholamines on ovarian contractility were also considered. Contractions were recorded at intervals from 5 to 17 hours after HCG administration. Ovaries were observed for spontaneous contractility and for response to norpinephrinc, phenoxybenzatninc, isoproterenol and propranolol. Autonomic drugs were administered into the abdominal aorta in the in vivo preparations and/or added to the bath for in vitro study. Contractions were present in almost all ovaries examined in vivo. Amplitude and frequency of ovarian contractions increased as the time of anticipated ovulation was approached. Norepinephrine was effective in instituting contractions in those ovaries which did not contract spontaneously. In all instances, phenoxy-benzamine blocked contractions. Propranolol in general intensified the contractile pattern. The relationship of these findings to the ovulatory process is discussed.

Original languageEnglish (US)
Pages (from-to)225-236
Number of pages12
JournalObstetrics and gynecology
Volume39
Issue number2
StatePublished - Feb 1972
Externally publishedYes

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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