Effects of candesartan and PD123319 on responses to angiotensin II in the anesthetized mouse

Trinity J. Bivalacqua; Ajay Dalal; David G. Lambert; Hunter C. Champion; Philip J. Kadowitz

Effects of candesartan and PD123319 on responses to angiotensin II in the anesthetized mouse

Trinity J. Bivalacqua, Ajay Dalal, David G. Lambert, Hunter C. Champion, Philip J. Kadowitz

Research output: Contribution to journal › Article › peer-review

Abstract

The effects of candesartan (30 μg/kg iv) and PD123319 (10 mg/kg iv) on changes in systemic arterial pressure in response to angiotensin II (AngII) were investigated in the anesthetized mouse. Intravenous injections of AngII caused dose-related increases in systemic arterial pressure. Pressor responses to AngII were attenuated by candesartan but were not altered by PD123319. Neither candesartan nor PD123319 had a significant effect on baseline systemic arterial pressure or on the increase in arterial pressure in response to norepinephrine. The present results suggest that increases in systemic arterial pressure in response to AngII in the anesthetized mouse are mediated by AT₁ receptors and that AT₂ receptors do not modulate the pressor response to AngII.

Original language	English (US)
Pages (from-to)	S98-S100
Journal	Journal of the American Society of Nephrology
Volume	10
Issue number	1 SUPPL. 11
State	Published - Jan 1 1999
Externally published	Yes

ASJC Scopus subject areas

Nephrology

Cite this

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title = "Effects of candesartan and PD123319 on responses to angiotensin II in the anesthetized mouse",

abstract = "The effects of candesartan (30 μg/kg iv) and PD123319 (10 mg/kg iv) on changes in systemic arterial pressure in response to angiotensin II (AngII) were investigated in the anesthetized mouse. Intravenous injections of AngII caused dose-related increases in systemic arterial pressure. Pressor responses to AngII were attenuated by candesartan but were not altered by PD123319. Neither candesartan nor PD123319 had a significant effect on baseline systemic arterial pressure or on the increase in arterial pressure in response to norepinephrine. The present results suggest that increases in systemic arterial pressure in response to AngII in the anesthetized mouse are mediated by AT1 receptors and that AT2 receptors do not modulate the pressor response to AngII.",

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AU - Bivalacqua, Trinity J.

AU - Dalal, Ajay

AU - Lambert, David G.

AU - Champion, Hunter C.

AU - Kadowitz, Philip J.

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N2 - The effects of candesartan (30 μg/kg iv) and PD123319 (10 mg/kg iv) on changes in systemic arterial pressure in response to angiotensin II (AngII) were investigated in the anesthetized mouse. Intravenous injections of AngII caused dose-related increases in systemic arterial pressure. Pressor responses to AngII were attenuated by candesartan but were not altered by PD123319. Neither candesartan nor PD123319 had a significant effect on baseline systemic arterial pressure or on the increase in arterial pressure in response to norepinephrine. The present results suggest that increases in systemic arterial pressure in response to AngII in the anesthetized mouse are mediated by AT1 receptors and that AT2 receptors do not modulate the pressor response to AngII.

AB - The effects of candesartan (30 μg/kg iv) and PD123319 (10 mg/kg iv) on changes in systemic arterial pressure in response to angiotensin II (AngII) were investigated in the anesthetized mouse. Intravenous injections of AngII caused dose-related increases in systemic arterial pressure. Pressor responses to AngII were attenuated by candesartan but were not altered by PD123319. Neither candesartan nor PD123319 had a significant effect on baseline systemic arterial pressure or on the increase in arterial pressure in response to norepinephrine. The present results suggest that increases in systemic arterial pressure in response to AngII in the anesthetized mouse are mediated by AT1 receptors and that AT2 receptors do not modulate the pressor response to AngII.

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Effects of candesartan and PD123319 on responses to angiotensin II in the anesthetized mouse

Abstract

ASJC Scopus subject areas

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