Effects of camptothecin, a topoisomerase I inhibitor, on Plasmodium falciparum

Annette L. Bodley, Jared N. Cumming, Theresa A. Shapiro

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


Currently, the treatment of falciparum malaria is seriously compromised by spreading drug resistance. We studied the effects of camptothecin, a potent and specific topoisomerase I inhibitor, on erythrocytic malaria parasites in vitro. In Plasmodium falciparum, camptothecin trapped protein-DNA complexes, inhibited nucleic acid biosynthesis, and was cytotoxic. These results provide proof for the concept that topoisomerase I is a vulnerable target for new antimalarial drug development.

Original languageEnglish (US)
Pages (from-to)709-711
Number of pages3
JournalBiochemical Pharmacology
Issue number5
StatePublished - Mar 1 1998


  • Camptothecin
  • Malaria
  • Plasmodium falciparum
  • Topoisomerase

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology


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