Abstract
Currently, the treatment of falciparum malaria is seriously compromised by spreading drug resistance. We studied the effects of camptothecin, a potent and specific topoisomerase I inhibitor, on erythrocytic malaria parasites in vitro. In Plasmodium falciparum, camptothecin trapped protein-DNA complexes, inhibited nucleic acid biosynthesis, and was cytotoxic. These results provide proof for the concept that topoisomerase I is a vulnerable target for new antimalarial drug development.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 709-711 |
| Number of pages | 3 |
| Journal | Biochemical Pharmacology |
| Volume | 55 |
| Issue number | 5 |
| DOIs | |
| State | Published - Mar 1 1998 |
Keywords
- Camptothecin
- Malaria
- Plasmodium falciparum
- Topoisomerase
ASJC Scopus subject areas
- Biochemistry
- Pharmacology
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Bodley, A. L., Cumming, J. N., & Shapiro, T. A. (1998). Effects of camptothecin, a topoisomerase I inhibitor, on Plasmodium falciparum. Biochemical Pharmacology, 55(5), 709-711. https://doi.org/10.1016/S0006-2952(97)00556-X