Effects of camptothecin, a topoisomerase I inhibitor, on Plasmodium falciparum

Annette L. Bodley; Jared N. Cumming; Theresa A. Shapiro

doi:10.1016/S0006-2952(97)00556-X

Effects of camptothecin, a topoisomerase I inhibitor, on Plasmodium falciparum

Annette L. Bodley, Jared N. Cumming, Theresa A. Shapiro

School of Medicine

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

Currently, the treatment of falciparum malaria is seriously compromised by spreading drug resistance. We studied the effects of camptothecin, a potent and specific topoisomerase I inhibitor, on erythrocytic malaria parasites in vitro. In Plasmodium falciparum, camptothecin trapped protein-DNA complexes, inhibited nucleic acid biosynthesis, and was cytotoxic. These results provide proof for the concept that topoisomerase I is a vulnerable target for new antimalarial drug development.

Original language	English (US)
Pages (from-to)	709-711
Number of pages	3
Journal	Biochemical Pharmacology
Volume	55
Issue number	5
DOIs	https://doi.org/10.1016/S0006-2952(97)00556-X
State	Published - Mar 1 1998

Keywords

Camptothecin
Malaria
Plasmodium falciparum
Topoisomerase

ASJC Scopus subject areas

Biochemistry
Pharmacology

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10.1016/S0006-2952(97)00556-X

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title = "Effects of camptothecin, a topoisomerase I inhibitor, on Plasmodium falciparum",

abstract = "Currently, the treatment of falciparum malaria is seriously compromised by spreading drug resistance. We studied the effects of camptothecin, a potent and specific topoisomerase I inhibitor, on erythrocytic malaria parasites in vitro. In Plasmodium falciparum, camptothecin trapped protein-DNA complexes, inhibited nucleic acid biosynthesis, and was cytotoxic. These results provide proof for the concept that topoisomerase I is a vulnerable target for new antimalarial drug development.",

keywords = "Camptothecin, Malaria, Plasmodium falciparum, Topoisomerase",

author = "Bodley, {Annette L.} and Cumming, {Jared N.} and Shapiro, {Theresa A.}",

note = "Funding Information: We thank Professor Gary Posner for support of J. N. C., and Drs. Edward Shapiro and Daoid Bush for statistical odelice. This work was supported by rhe Burroughs Wellcome Fund and by NIH, NCRR, OPD-GCRC Grant RR00722.",

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T1 - Effects of camptothecin, a topoisomerase I inhibitor, on Plasmodium falciparum

AU - Bodley, Annette L.

AU - Cumming, Jared N.

AU - Shapiro, Theresa A.

N1 - Funding Information: We thank Professor Gary Posner for support of J. N. C., and Drs. Edward Shapiro and Daoid Bush for statistical odelice. This work was supported by rhe Burroughs Wellcome Fund and by NIH, NCRR, OPD-GCRC Grant RR00722.

PY - 1998/3/1

Y1 - 1998/3/1

N2 - Currently, the treatment of falciparum malaria is seriously compromised by spreading drug resistance. We studied the effects of camptothecin, a potent and specific topoisomerase I inhibitor, on erythrocytic malaria parasites in vitro. In Plasmodium falciparum, camptothecin trapped protein-DNA complexes, inhibited nucleic acid biosynthesis, and was cytotoxic. These results provide proof for the concept that topoisomerase I is a vulnerable target for new antimalarial drug development.

AB - Currently, the treatment of falciparum malaria is seriously compromised by spreading drug resistance. We studied the effects of camptothecin, a potent and specific topoisomerase I inhibitor, on erythrocytic malaria parasites in vitro. In Plasmodium falciparum, camptothecin trapped protein-DNA complexes, inhibited nucleic acid biosynthesis, and was cytotoxic. These results provide proof for the concept that topoisomerase I is a vulnerable target for new antimalarial drug development.

KW - Camptothecin

KW - Malaria

KW - Plasmodium falciparum

KW - Topoisomerase

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Effects of camptothecin, a topoisomerase I inhibitor, on Plasmodium falciparum

Abstract

Keywords

ASJC Scopus subject areas

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