Effects of Calorie Restriction in Obese Older Adults

The CROSSROADS Randomized Controlled Trial

Jamy D. Ard, Barbara Gower, Gary Hunter, Christine S. Ritchie, David L Roth, Amy Goss, Brooks C. Wingo, Eric V. Bodner, Cynthia J. Brown, David Bryan, David R. Buys, Marilyn C. Haas, Akilah Dulin Keita, Lee Anne Flagg, Courtney P. Williams, Julie L. Locher

Research output: Contribution to journalArticle

Abstract

Background: We lack a comprehensive assessment of the risks and benefits of calorie restriction in older adults at high risk for cardiometabolic disease. Calorie restriction may reduce visceral adipose tissue (VAT) but also have negative effects on lean mass and quality of life.

Methods: We conducted a 52-week, randomized controlled trial involving 164 older adults with obesity taking at least one medication for hyperlipidemia, hypertension, or diabetes. Interventions included an exercise intervention alone (Exercise), or with diet modification and body weight maintenance (Maintenance), or with diet modification and energy restriction (Weight Loss). The primary outcome was change in VAT at 12 months. Secondary outcomes included cardiometabolic risk factors, functional status, and quality of life.

Results: A total of 148 participants had measured weight at 12 months. Despite loss of -1.6% ± 0.3% body fat and 4.1% ± 0.7% initial body weight, Weight Loss did not have statistically greater loss of VAT (-192.6 ± 185.2 cm3) or lean mass (-0.4 ± 0.3 kg) compared with Exercise (VAT = -21.9 ± 173.7 cm3; lean mass = 0.3 ± 0.3 kg). Quality of life improved in all groups with no differences between groups. No significant changes in physical function were observed. Weight Loss had significantly greater improvements in blood glucose (-8.3 ± 3.6 mg/dL, p < .05) and HDL-cholesterol (5.3 ± 1.9, p < .01) compared with Exercise. There were no group differences in the frequency of adverse events.

Conclusions: While moderate calorie restriction did not significantly decrease VAT in older adults at high risk for cardiometabolic disease, it did reduce total body fat and cardiometabolic risk factors without significantly more adverse events and lean mass loss.

Original languageEnglish (US)
Pages (from-to)73-80
Number of pages8
JournalThe journals of gerontology. Series A, Biological sciences and medical sciences
Volume73
Issue number1
DOIs
StatePublished - Dec 12 2017
Externally publishedYes

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Intra-Abdominal Fat
Randomized Controlled Trials
Diet Therapy
Weight Loss
Quality of Life
Adipose Tissue
Hyperlipidemias
HDL Cholesterol
Blood Glucose
Obesity
Body Weight
Maintenance
Hypertension
Weights and Measures

Keywords

  • cardiometabolic risk
  • physical function
  • quality of life
  • visceral adipose tissue
  • Weight reduction

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

Effects of Calorie Restriction in Obese Older Adults : The CROSSROADS Randomized Controlled Trial. / Ard, Jamy D.; Gower, Barbara; Hunter, Gary; Ritchie, Christine S.; Roth, David L; Goss, Amy; Wingo, Brooks C.; Bodner, Eric V.; Brown, Cynthia J.; Bryan, David; Buys, David R.; Haas, Marilyn C.; Keita, Akilah Dulin; Flagg, Lee Anne; Williams, Courtney P.; Locher, Julie L.

In: The journals of gerontology. Series A, Biological sciences and medical sciences, Vol. 73, No. 1, 12.12.2017, p. 73-80.

Research output: Contribution to journalArticle

Ard, JD, Gower, B, Hunter, G, Ritchie, CS, Roth, DL, Goss, A, Wingo, BC, Bodner, EV, Brown, CJ, Bryan, D, Buys, DR, Haas, MC, Keita, AD, Flagg, LA, Williams, CP & Locher, JL 2017, 'Effects of Calorie Restriction in Obese Older Adults: The CROSSROADS Randomized Controlled Trial', The journals of gerontology. Series A, Biological sciences and medical sciences, vol. 73, no. 1, pp. 73-80. https://doi.org/10.1093/gerona/glw237
Ard, Jamy D. ; Gower, Barbara ; Hunter, Gary ; Ritchie, Christine S. ; Roth, David L ; Goss, Amy ; Wingo, Brooks C. ; Bodner, Eric V. ; Brown, Cynthia J. ; Bryan, David ; Buys, David R. ; Haas, Marilyn C. ; Keita, Akilah Dulin ; Flagg, Lee Anne ; Williams, Courtney P. ; Locher, Julie L. / Effects of Calorie Restriction in Obese Older Adults : The CROSSROADS Randomized Controlled Trial. In: The journals of gerontology. Series A, Biological sciences and medical sciences. 2017 ; Vol. 73, No. 1. pp. 73-80.
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