TY - JOUR
T1 - Effects of bone marrow cell transplant on thyroid function in an I 131-induced low T4 and elevated TSH rat model
AU - Guajardo-Salinas, Gustavo E.
AU - Carvajal, Juan A.
AU - Gaytan-Ramos, Ángel A.
AU - Arroyo, Luis
AU - López-Reyes, Alberto G.
AU - Islas, José F.
AU - Cano, Beiman G.
AU - Arroyo-Currás, Netzahualcoyótl
AU - Dávalos, Alfredo
AU - Madrid, Gloria
AU - Moreno-Cuevas, Jorge E.
PY - 2007
Y1 - 2007
N2 - Background. We developed a study using low dose radioactive iodine creating an animal model of transient elevation of thyroid stimulating hormone (TSH). Male derived bone marrow cells were transplanted to asses their effect on thyroid function and their capability to repair the thyroid parenchyma. Results. At 40 an 80 days after I131 treatment, the study groups TSH and T4 serum values both increased and decreased significantly respectively compared to the negative control group. Eight weeks after cell transplantation, neither TSH nor T4 showed a significant difference in any group. The mean number of SRY gene copies found in group I (Left Intracardiac Transplant) was 523.3 and those in group II (Intrathyroid Transplant) were only 73. Group III (No Transplant) and IV had no copies. Group I presented a partial restore of the histological pattern of rat thyroid with approximately 20% - 30% of normal-sized follicles. Group II did not show any histological differences compared to group III (Positive control). Conclusion. Both a significant increase of TSH and decrease of T4 can be induced as early as day 40 after a low dose of I131 in rats. Restore of normal thyroid function can be spontaneously achieved after using a low dose RAI in a rat model. The use of BM derived cells did not affect the re-establishment of thyroid function and might help restore the normal architecture after treatment with RAI.
AB - Background. We developed a study using low dose radioactive iodine creating an animal model of transient elevation of thyroid stimulating hormone (TSH). Male derived bone marrow cells were transplanted to asses their effect on thyroid function and their capability to repair the thyroid parenchyma. Results. At 40 an 80 days after I131 treatment, the study groups TSH and T4 serum values both increased and decreased significantly respectively compared to the negative control group. Eight weeks after cell transplantation, neither TSH nor T4 showed a significant difference in any group. The mean number of SRY gene copies found in group I (Left Intracardiac Transplant) was 523.3 and those in group II (Intrathyroid Transplant) were only 73. Group III (No Transplant) and IV had no copies. Group I presented a partial restore of the histological pattern of rat thyroid with approximately 20% - 30% of normal-sized follicles. Group II did not show any histological differences compared to group III (Positive control). Conclusion. Both a significant increase of TSH and decrease of T4 can be induced as early as day 40 after a low dose of I131 in rats. Restore of normal thyroid function can be spontaneously achieved after using a low dose RAI in a rat model. The use of BM derived cells did not affect the re-establishment of thyroid function and might help restore the normal architecture after treatment with RAI.
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U2 - 10.1186/1477-5751-6-1
DO - 10.1186/1477-5751-6-1
M3 - Article
C2 - 17233913
AN - SCOPUS:33846671776
SN - 1477-5751
VL - 6
JO - Journal of Negative Results in BioMedicine
JF - Journal of Negative Results in BioMedicine
M1 - 1
ER -