Effects of biodegradable polymers on macrophage functions in vitro

K. Tanner, S. Kadiyala, C. Frondoza, K. Leong

Research output: Contribution to conferencePaperpeer-review

Abstract

In this study, we compared the effects of BPA-PP with that of polyurethane (PU), a suspected toxin and a widely used biodegradable polymer (polylactic acid, PLA). The macrophage cell culture model for evaluating biocompatibility can effectively screen polymer candidates for drug delivery systems. PLA (Polyacetic Acid) (a polymer successfully used in this application) and BPA-PP did not affect macrophage DNA synthesis, protein synthesis, or interleukin-1 production. However, PU was found to be cytotoxic and impaired macrophage functional ability.

Original languageEnglish (US)
Number of pages1
StatePublished - Jan 1 1991
Event17th Annual Meeting of the Society for Biomaterials in conjunction with the 23rd International Biomaterials Symposium - Scottsdale, AZ, USA
Duration: May 1 1991May 5 1991

Other

Other17th Annual Meeting of the Society for Biomaterials in conjunction with the 23rd International Biomaterials Symposium
CityScottsdale, AZ, USA
Period5/1/915/5/91

ASJC Scopus subject areas

  • Materials Science(all)

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