Effects of biodegradable polymers on macrophage functions in vitro

K. Tanner, S. Kadiyala, C. Frondoza, K. Leong

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this study, we compared the effects of BPA-PP with that of polyurethane (PU), a suspected toxin and a widely used biodegradable polymer (polylactic acid, PLA). The macrophage cell culture model for evaluating biocompatibility can effectively screen polymer candidates for drug delivery systems. PLA (Polyacetic Acid) (a polymer successfully used in this application) and BPA-PP did not affect macrophage DNA synthesis, protein synthesis, or interleukin-1 production. However, PU was found to be cytotoxic and impaired macrophage functional ability.

Original languageEnglish (US)
Title of host publicationTransactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium
PublisherPubl by Soc for Biomaterials
Pages182
Number of pages1
Volume14
Publication statusPublished - 1991
Event17th Annual Meeting of the Society for Biomaterials in conjunction with the 23rd International Biomaterials Symposium - Scottsdale, AZ, USA
Duration: May 1 1991May 5 1991

Other

Other17th Annual Meeting of the Society for Biomaterials in conjunction with the 23rd International Biomaterials Symposium
CityScottsdale, AZ, USA
Period5/1/915/5/91

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ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Tanner, K., Kadiyala, S., Frondoza, C., & Leong, K. (1991). Effects of biodegradable polymers on macrophage functions in vitro. In Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium (Vol. 14, pp. 182). Publ by Soc for Biomaterials.