Effects of biodegradable hydrogel spacer injection on contralateral submandibular gland sparing in radiotherapy for head and neck cancers

Avani D. Rao, Stephanie Coquia, Robert De Jong, Christine Gourin, Brandi Page, Diane Latronico, Samson Dah, Lin Su, Stephen Clarke, Jeffrey Schultz, Lauren M. Rosati, Carole Fakhry, John Wong, Theodore DeWeese, Harry Quon, Kai Ding, Ana Ponce Kiess

Research output: Contribution to journalArticle

Abstract

Xerostomia is the most common late toxicity after head and neck radiation. We demonstrate injection of a hydrogel spacer anteriorly displacing the submandibular gland. This procedure enables reduced dose to the displaced submandibular gland in cadaveric models of oropharynx cancer treated with IMRT, with potential implications in reducing xerostomia risk.

Original languageEnglish (US)
JournalRadiotherapy and Oncology
DOIs
StateAccepted/In press - 2017

Fingerprint

Xerostomia
Submandibular Gland
Hydrogel
Head and Neck Neoplasms
Radiotherapy
Oropharyngeal Neoplasms
Injections
Neck
Head
Radiation

Keywords

  • Radiation therapy
  • Submandibular gland
  • Xerostomia

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

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title = "Effects of biodegradable hydrogel spacer injection on contralateral submandibular gland sparing in radiotherapy for head and neck cancers",
abstract = "Xerostomia is the most common late toxicity after head and neck radiation. We demonstrate injection of a hydrogel spacer anteriorly displacing the submandibular gland. This procedure enables reduced dose to the displaced submandibular gland in cadaveric models of oropharynx cancer treated with IMRT, with potential implications in reducing xerostomia risk.",
keywords = "Radiation therapy, Submandibular gland, Xerostomia",
author = "Rao, {Avani D.} and Stephanie Coquia and {De Jong}, Robert and Christine Gourin and Brandi Page and Diane Latronico and Samson Dah and Lin Su and Stephen Clarke and Jeffrey Schultz and Rosati, {Lauren M.} and Carole Fakhry and John Wong and Theodore DeWeese and Harry Quon and Kai Ding and Kiess, {Ana Ponce}",
year = "2017",
doi = "10.1016/j.radonc.2017.09.017",
language = "English (US)",
journal = "Radiotherapy and Oncology",
issn = "0167-8140",
publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Effects of biodegradable hydrogel spacer injection on contralateral submandibular gland sparing in radiotherapy for head and neck cancers

AU - Rao, Avani D.

AU - Coquia, Stephanie

AU - De Jong, Robert

AU - Gourin, Christine

AU - Page, Brandi

AU - Latronico, Diane

AU - Dah, Samson

AU - Su, Lin

AU - Clarke, Stephen

AU - Schultz, Jeffrey

AU - Rosati, Lauren M.

AU - Fakhry, Carole

AU - Wong, John

AU - DeWeese, Theodore

AU - Quon, Harry

AU - Ding, Kai

AU - Kiess, Ana Ponce

PY - 2017

Y1 - 2017

N2 - Xerostomia is the most common late toxicity after head and neck radiation. We demonstrate injection of a hydrogel spacer anteriorly displacing the submandibular gland. This procedure enables reduced dose to the displaced submandibular gland in cadaveric models of oropharynx cancer treated with IMRT, with potential implications in reducing xerostomia risk.

AB - Xerostomia is the most common late toxicity after head and neck radiation. We demonstrate injection of a hydrogel spacer anteriorly displacing the submandibular gland. This procedure enables reduced dose to the displaced submandibular gland in cadaveric models of oropharynx cancer treated with IMRT, with potential implications in reducing xerostomia risk.

KW - Radiation therapy

KW - Submandibular gland

KW - Xerostomia

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U2 - 10.1016/j.radonc.2017.09.017

DO - 10.1016/j.radonc.2017.09.017

M3 - Article

C2 - 28985953

AN - SCOPUS:85030482858

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

SN - 0167-8140

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