Effects of biodegradable hydrogel spacer injection on contralateral submandibular gland sparing in radiotherapy for head and neck cancers

Avani D. Rao, Stephanie Coquia, Robert De Jong, Christine Gourin, Brandi Page, Diane Latronico, Samson Dah, Lin Su, Stephen Clarke, Jeffrey Schultz, Lauren M. Rosati, Carole Fakhry, John Wong, Theodore L. DeWeese, Harry Quon, Kai Ding, Ana Kiess

Research output: Contribution to journalArticlepeer-review

Abstract

Xerostomia is the most common late toxicity after head and neck radiation. We demonstrate injection of a hydrogel spacer anteriorly displacing the submandibular gland. This procedure enables reduced dose to the displaced submandibular gland in cadaveric models of oropharynx cancer treated with IMRT, with potential implications in reducing xerostomia risk.

Original languageEnglish (US)
Pages (from-to)96-99
Number of pages4
JournalRadiotherapy and Oncology
Volume126
Issue number1
DOIs
StatePublished - Jan 2018

Keywords

  • Radiation therapy
  • Submandibular gland
  • Xerostomia

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging

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