Effects of aromatase inhibition vs. testosterone in older men with low testosterone: randomized-controlled trial

Jenny Pena Dias, D. Melvin, Eleanor Marie Simonsick, O. Carlson, M. D. Shardell, L. Ferrucci, C. W. Chia, S. Basaria, J. M. Egan

Research output: Contribution to journalArticle

Abstract

Aging in men is associated with loss of bone mass, impaired physical function and altered body composition. The objective of this proof-of-concept randomized, double-blind, placebo-controlled, parallel-group, single-center trial was to determine the relative effects of testosterone (T) and estradiol (E2) on bone mineral density, body composition, and physical performance in older men. The primary outcome was lumbar spine bone mineral density (BMD), and secondary outcomes were body composition, muscle strength, gait speed, and sex hormone concentrations. Forty three men (age range, 65-82 years; mean age 71 years) with low total T levels 500 ng/dL, p <0.05) compared to baseline T values remained stable throughout the duration of the trial. At 12 months, TT improved the primary outcome of lumbar spine BMD (p <0.01).Both interventions improved knee strength at 12 months compared to baseline (p <0.05) while lean body mass significantly increased only in the AI group at 6 and 12 months (1.49 ± 0.38 kg, p <0.01; 1.24 ± 0.39 kg, p <0.05, respectively) compared to baseline. Interestingly, TT improved fast gait speed at 3 and 12 months (p <0.01, p <0.05, respectively). In summary, this proof-of-concept study confirms that aromatization of T is required for maintaining BMD in older men with low-T levels. The trial also uncovered the novel finding that aromatization of T is required for improvement in fast gait speed, an observation that needs to be verified in future studies.

Original languageEnglish (US)
Pages (from-to)33-40
Number of pages8
JournalAndrology
Volume4
Issue number1
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

Fingerprint

Aromatase
Bone Density
Testosterone
Randomized Controlled Trials
Body Composition
Spine
Gonadal Steroid Hormones
Muscle Strength
Estradiol
Knee
Placebos
Observation
Bone and Bones
Walking Speed

Keywords

  • Aging
  • Aromatase inhibition
  • Bone
  • Gait speed
  • Muscle strength
  • Testosterone

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Reproductive Medicine
  • Urology

Cite this

Effects of aromatase inhibition vs. testosterone in older men with low testosterone : randomized-controlled trial. / Pena Dias, Jenny; Melvin, D.; Simonsick, Eleanor Marie; Carlson, O.; Shardell, M. D.; Ferrucci, L.; Chia, C. W.; Basaria, S.; Egan, J. M.

In: Andrology, Vol. 4, No. 1, 01.01.2016, p. 33-40.

Research output: Contribution to journalArticle

Pena Dias, J, Melvin, D, Simonsick, EM, Carlson, O, Shardell, MD, Ferrucci, L, Chia, CW, Basaria, S & Egan, JM 2016, 'Effects of aromatase inhibition vs. testosterone in older men with low testosterone: randomized-controlled trial', Andrology, vol. 4, no. 1, pp. 33-40. https://doi.org/10.1111/andr.12126
Pena Dias, Jenny ; Melvin, D. ; Simonsick, Eleanor Marie ; Carlson, O. ; Shardell, M. D. ; Ferrucci, L. ; Chia, C. W. ; Basaria, S. ; Egan, J. M. / Effects of aromatase inhibition vs. testosterone in older men with low testosterone : randomized-controlled trial. In: Andrology. 2016 ; Vol. 4, No. 1. pp. 33-40.
@article{5065f05cfa5b4995905a6772af8fd9f8,
title = "Effects of aromatase inhibition vs. testosterone in older men with low testosterone: randomized-controlled trial",
abstract = "Aging in men is associated with loss of bone mass, impaired physical function and altered body composition. The objective of this proof-of-concept randomized, double-blind, placebo-controlled, parallel-group, single-center trial was to determine the relative effects of testosterone (T) and estradiol (E2) on bone mineral density, body composition, and physical performance in older men. The primary outcome was lumbar spine bone mineral density (BMD), and secondary outcomes were body composition, muscle strength, gait speed, and sex hormone concentrations. Forty three men (age range, 65-82 years; mean age 71 years) with low total T levels 500 ng/dL, p <0.05) compared to baseline T values remained stable throughout the duration of the trial. At 12 months, TT improved the primary outcome of lumbar spine BMD (p <0.01).Both interventions improved knee strength at 12 months compared to baseline (p <0.05) while lean body mass significantly increased only in the AI group at 6 and 12 months (1.49 ± 0.38 kg, p <0.01; 1.24 ± 0.39 kg, p <0.05, respectively) compared to baseline. Interestingly, TT improved fast gait speed at 3 and 12 months (p <0.01, p <0.05, respectively). In summary, this proof-of-concept study confirms that aromatization of T is required for maintaining BMD in older men with low-T levels. The trial also uncovered the novel finding that aromatization of T is required for improvement in fast gait speed, an observation that needs to be verified in future studies.",
keywords = "Aging, Aromatase inhibition, Bone, Gait speed, Muscle strength, Testosterone",
author = "{Pena Dias}, Jenny and D. Melvin and Simonsick, {Eleanor Marie} and O. Carlson and Shardell, {M. D.} and L. Ferrucci and Chia, {C. W.} and S. Basaria and Egan, {J. M.}",
year = "2016",
month = "1",
day = "1",
doi = "10.1111/andr.12126",
language = "English (US)",
volume = "4",
pages = "33--40",
journal = "Andrology",
issn = "2047-2919",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

TY - JOUR

T1 - Effects of aromatase inhibition vs. testosterone in older men with low testosterone

T2 - randomized-controlled trial

AU - Pena Dias, Jenny

AU - Melvin, D.

AU - Simonsick, Eleanor Marie

AU - Carlson, O.

AU - Shardell, M. D.

AU - Ferrucci, L.

AU - Chia, C. W.

AU - Basaria, S.

AU - Egan, J. M.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Aging in men is associated with loss of bone mass, impaired physical function and altered body composition. The objective of this proof-of-concept randomized, double-blind, placebo-controlled, parallel-group, single-center trial was to determine the relative effects of testosterone (T) and estradiol (E2) on bone mineral density, body composition, and physical performance in older men. The primary outcome was lumbar spine bone mineral density (BMD), and secondary outcomes were body composition, muscle strength, gait speed, and sex hormone concentrations. Forty three men (age range, 65-82 years; mean age 71 years) with low total T levels 500 ng/dL, p <0.05) compared to baseline T values remained stable throughout the duration of the trial. At 12 months, TT improved the primary outcome of lumbar spine BMD (p <0.01).Both interventions improved knee strength at 12 months compared to baseline (p <0.05) while lean body mass significantly increased only in the AI group at 6 and 12 months (1.49 ± 0.38 kg, p <0.01; 1.24 ± 0.39 kg, p <0.05, respectively) compared to baseline. Interestingly, TT improved fast gait speed at 3 and 12 months (p <0.01, p <0.05, respectively). In summary, this proof-of-concept study confirms that aromatization of T is required for maintaining BMD in older men with low-T levels. The trial also uncovered the novel finding that aromatization of T is required for improvement in fast gait speed, an observation that needs to be verified in future studies.

AB - Aging in men is associated with loss of bone mass, impaired physical function and altered body composition. The objective of this proof-of-concept randomized, double-blind, placebo-controlled, parallel-group, single-center trial was to determine the relative effects of testosterone (T) and estradiol (E2) on bone mineral density, body composition, and physical performance in older men. The primary outcome was lumbar spine bone mineral density (BMD), and secondary outcomes were body composition, muscle strength, gait speed, and sex hormone concentrations. Forty three men (age range, 65-82 years; mean age 71 years) with low total T levels 500 ng/dL, p <0.05) compared to baseline T values remained stable throughout the duration of the trial. At 12 months, TT improved the primary outcome of lumbar spine BMD (p <0.01).Both interventions improved knee strength at 12 months compared to baseline (p <0.05) while lean body mass significantly increased only in the AI group at 6 and 12 months (1.49 ± 0.38 kg, p <0.01; 1.24 ± 0.39 kg, p <0.05, respectively) compared to baseline. Interestingly, TT improved fast gait speed at 3 and 12 months (p <0.01, p <0.05, respectively). In summary, this proof-of-concept study confirms that aromatization of T is required for maintaining BMD in older men with low-T levels. The trial also uncovered the novel finding that aromatization of T is required for improvement in fast gait speed, an observation that needs to be verified in future studies.

KW - Aging

KW - Aromatase inhibition

KW - Bone

KW - Gait speed

KW - Muscle strength

KW - Testosterone

UR - http://www.scopus.com/inward/record.url?scp=84955210370&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84955210370&partnerID=8YFLogxK

U2 - 10.1111/andr.12126

DO - 10.1111/andr.12126

M3 - Article

C2 - 26588809

AN - SCOPUS:84955210370

VL - 4

SP - 33

EP - 40

JO - Andrology

JF - Andrology

SN - 2047-2919

IS - 1

ER -