The role of thyroglobulin antibody in spontaneous autoimmune thyroiditis was investigated. Obese strain (OS) chickens are genetically susceptible to severe or mild disease depending upon their histocompatibility types (B1B1 or B4B4, respectively). They were repeatedly injected with OS serum containing a high titer of thyroglobulin antibody. This regimen significantly increased lymphoid infiltration of the thyroid gland in the mildly afflicted B4B4 chickens but had no observable effect on B1B1 chickens genetically predisposed to severe thyroiditis. The removal of thyroglobulin antibody from the serum prior to injection ablated the activity of the serum. This same OS serum pool did not, however, cause thyroiditis when injected into normal Cornell strain (CS) B1B1 chickens (neonatally thymectomized or unoperated). It is concluded, therefore, that thyroglobulin antibody plays a pathogenic role in this spontaneously occurring autoimmune thyroiditis, although other factors present in OS (but not CS) chickens are also required for the disease to develop.
ASJC Scopus subject areas
- Immunology and Allergy
- Pathology and Forensic Medicine