TY - JOUR
T1 - Effects of antiserum containing thyroglobulin antibody on the chicken thyroid gland
AU - Jaroszewski, Jan
AU - Sundick, Roy S.
AU - Rose, Noel R.
N1 - Funding Information:
The authors wish to acknowledge the help of Dr. Kenneth Morrison in setting up the immunoadsor-bent column. The excellent technical assistance of Ms. Halina Pietraszkiewicz and Ms. Margaret Clark is appreciated. This work was supported by Research Grants AM20028 and AGO0634 from the National Institutes of Health.
PY - 1978/5
Y1 - 1978/5
N2 - The role of thyroglobulin antibody in spontaneous autoimmune thyroiditis was investigated. Obese strain (OS) chickens are genetically susceptible to severe or mild disease depending upon their histocompatibility types (B1B1 or B4B4, respectively). They were repeatedly injected with OS serum containing a high titer of thyroglobulin antibody. This regimen significantly increased lymphoid infiltration of the thyroid gland in the mildly afflicted B4B4 chickens but had no observable effect on B1B1 chickens genetically predisposed to severe thyroiditis. The removal of thyroglobulin antibody from the serum prior to injection ablated the activity of the serum. This same OS serum pool did not, however, cause thyroiditis when injected into normal Cornell strain (CS) B1B1 chickens (neonatally thymectomized or unoperated). It is concluded, therefore, that thyroglobulin antibody plays a pathogenic role in this spontaneously occurring autoimmune thyroiditis, although other factors present in OS (but not CS) chickens are also required for the disease to develop.
AB - The role of thyroglobulin antibody in spontaneous autoimmune thyroiditis was investigated. Obese strain (OS) chickens are genetically susceptible to severe or mild disease depending upon their histocompatibility types (B1B1 or B4B4, respectively). They were repeatedly injected with OS serum containing a high titer of thyroglobulin antibody. This regimen significantly increased lymphoid infiltration of the thyroid gland in the mildly afflicted B4B4 chickens but had no observable effect on B1B1 chickens genetically predisposed to severe thyroiditis. The removal of thyroglobulin antibody from the serum prior to injection ablated the activity of the serum. This same OS serum pool did not, however, cause thyroiditis when injected into normal Cornell strain (CS) B1B1 chickens (neonatally thymectomized or unoperated). It is concluded, therefore, that thyroglobulin antibody plays a pathogenic role in this spontaneously occurring autoimmune thyroiditis, although other factors present in OS (but not CS) chickens are also required for the disease to develop.
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U2 - 10.1016/0090-1229(78)90013-2
DO - 10.1016/0090-1229(78)90013-2
M3 - Article
C2 - 657593
AN - SCOPUS:0018147308
SN - 0090-1229
VL - 10
SP - 95
EP - 103
JO - Clinical Immunology and Immunopathology
JF - Clinical Immunology and Immunopathology
IS - 1
ER -