Effects of an HIV peer prevention intervention on sexual and injecting risk behaviors among injecting drug users and their risk partners in Thai Nguyen, Vietnam: A randomized controlled trial

Vivian F. Go, Constantine Frangakis, Nguyen Le Minh, Carl A. Latkin, Tran Viet Ha, Tran Thi Mo, Teerada Sripaipan, Wendy Davis, Carla Zelaya, Pham The Vu, Yong Chen, David D. Celentano, Vu Minh Quan

Research output: Contribution to journalArticle

Abstract

Globally, 30% of new HIV infections outside sub-Saharan Africa involve injecting drug users (IDU) and in many countries, including Vietnam, HIV epidemics are concentrated among IDU. We conducted a randomized controlled trial in Thai Nguyen, Vietnam, to evaluate whether a peer oriented behavioral intervention could reduce injecting and sexual HIV risk behaviors among IDU and their network members. 419 HIV-negative index IDU aged 18 years or older and 516 injecting and sexual network members were enrolled. Each index participant was randomly assigned to receive a series of six small group peer educator-training sessions and three booster sessions in addition to HIV testing and counseling (HTC) (intervention; n=210) or HTC only (control; n=209). Follow-up, including HTC, was conducted at 3, 6, 9 and 12 months post-intervention. The proportion of unprotected sex dropped significantly from 49% to 27% (SE (difference)=3%, p<0.01) between baseline and the 3-month visit among all index-network member pairs. However, at 12 months, post-intervention, intervention participants had a 14% greater decline in unprotected sex relative to control participants (Wald test=10.8, df=4, p=0.03). This intervention effect is explained by trial participants assigned to the control arm who missed at least one standardized HTC session during follow-up and subsequently reported increased unprotected sex. The proportion of observed needle/syringe sharing dropped significantly between baseline and the 3-month visit (14% vs. 3%, SE (difference)=2%, p<0.01) and persisted until 12 months, but there was no difference across trial arms (Wald test=3.74, df=3, p=0.44).

Original languageEnglish (US)
Pages (from-to)154-164
Number of pages11
JournalSocial Science and Medicine
Volume96
DOIs
StatePublished - Nov 2013

Keywords

  • Evaluation
  • HIV
  • Injecting drug use
  • Intervention
  • Peer network
  • Randomized controlled trial
  • Vietnam

ASJC Scopus subject areas

  • Health(social science)
  • History and Philosophy of Science

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