Effects of an Exercise Program in Colon Cancer Patients Undergoing Chemotherapy

Jonna K. van Vulpen, Miranda J. Velthuis, Charlotte N. Steins Bisschop, Noémie Travier, Bram J W van den Buijs, Frank J G Backx, Maartje Los, Frans L G Erdkamp, Haiko J. Bloemendal, Miriam Koopman, Marnix A J de Roos, Marlies J. Verhaar, Daan ten Bokkel-Huinink, Elsken van der Wall, Petra H M Peeters, Anne M. May

Research output: Contribution to journalArticle

Abstract

PURPOSE: Fatigue is a common problem among colon cancer patients and typically increases during chemotherapy. Exercise during chemotherapy might have beneficial effects on fatigue. To investigate the short- and long-term effects of an exercise program in colon cancer patients during adjuvant treatment, the Physical Activity during Cancer Treatment (PACT) study was conducted. METHODS: In this multicenter randomized controlled trial, 33 colon cancer patients undergoing chemotherapy (21 men and 12 women) were randomly assigned to either a group receiving an 18-week supervised exercise program (n=17) or to usual care (n=16). The primary outcome was fatigue as measured by the Multidimensional Fatigue Inventory (MFI) and the Fatigue Quality List (FQL). Secondary outcomes were quality of life, physical fitness, anxiety, depression, body weight and chemotherapy completion rate. Outcome assessment took place at baseline, post-intervention (18 weeks) and at 36 weeks. RESULTS: Intention-to-treat mixed linear model analyses showed that patients in the intervention group experienced significantly less physical fatigue at 18 weeks and general fatigue at 36 weeks (mean between group differences: -3.2, 95% CI -6.2; -0.2, effect size (ES)=-0.9 and -2.7, 95% CI -5.2; -0.1, ES=-0.8 respectively), and reported higher physical functioning (12.3, 95% CI 3.3; 21.4, ES=1.0) compared to patients in the usual care group. CONCLUSION: The PACT trial shows that an 18-week supervised exercise program in colon cancer patients during chemotherapy is safe and feasible. The intervention significantly reduced physical fatigue at 18 weeks and general fatigue at 36 weeks. Considering the number of patients included in the present study, replication in a larger study population is required.

Original languageEnglish (US)
JournalMedicine and Science in Sports and Exercise
DOIs
StateAccepted/In press - Dec 21 2015
Externally publishedYes

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Colonic Neoplasms
Fatigue
Exercise
Drug Therapy
Physical Fitness
Linear Models
Neoplasms
Therapeutics
Anxiety
Randomized Controlled Trials
Body Weight
Quality of Life
Outcome Assessment (Health Care)
Depression
Equipment and Supplies
Population

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

van Vulpen, J. K., Velthuis, M. J., Steins Bisschop, C. N., Travier, N., van den Buijs, B. J. W., Backx, F. J. G., ... May, A. M. (Accepted/In press). Effects of an Exercise Program in Colon Cancer Patients Undergoing Chemotherapy. Medicine and Science in Sports and Exercise. https://doi.org/10.1249/MSS.0000000000000855

Effects of an Exercise Program in Colon Cancer Patients Undergoing Chemotherapy. / van Vulpen, Jonna K.; Velthuis, Miranda J.; Steins Bisschop, Charlotte N.; Travier, Noémie; van den Buijs, Bram J W; Backx, Frank J G; Los, Maartje; Erdkamp, Frans L G; Bloemendal, Haiko J.; Koopman, Miriam; de Roos, Marnix A J; Verhaar, Marlies J.; ten Bokkel-Huinink, Daan; van der Wall, Elsken; Peeters, Petra H M; May, Anne M.

In: Medicine and Science in Sports and Exercise, 21.12.2015.

Research output: Contribution to journalArticle

van Vulpen, JK, Velthuis, MJ, Steins Bisschop, CN, Travier, N, van den Buijs, BJW, Backx, FJG, Los, M, Erdkamp, FLG, Bloemendal, HJ, Koopman, M, de Roos, MAJ, Verhaar, MJ, ten Bokkel-Huinink, D, van der Wall, E, Peeters, PHM & May, AM 2015, 'Effects of an Exercise Program in Colon Cancer Patients Undergoing Chemotherapy', Medicine and Science in Sports and Exercise. https://doi.org/10.1249/MSS.0000000000000855
van Vulpen JK, Velthuis MJ, Steins Bisschop CN, Travier N, van den Buijs BJW, Backx FJG et al. Effects of an Exercise Program in Colon Cancer Patients Undergoing Chemotherapy. Medicine and Science in Sports and Exercise. 2015 Dec 21. https://doi.org/10.1249/MSS.0000000000000855
van Vulpen, Jonna K. ; Velthuis, Miranda J. ; Steins Bisschop, Charlotte N. ; Travier, Noémie ; van den Buijs, Bram J W ; Backx, Frank J G ; Los, Maartje ; Erdkamp, Frans L G ; Bloemendal, Haiko J. ; Koopman, Miriam ; de Roos, Marnix A J ; Verhaar, Marlies J. ; ten Bokkel-Huinink, Daan ; van der Wall, Elsken ; Peeters, Petra H M ; May, Anne M. / Effects of an Exercise Program in Colon Cancer Patients Undergoing Chemotherapy. In: Medicine and Science in Sports and Exercise. 2015.
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AU - Velthuis, Miranda J.

AU - Steins Bisschop, Charlotte N.

AU - Travier, Noémie

AU - van den Buijs, Bram J W

AU - Backx, Frank J G

AU - Los, Maartje

AU - Erdkamp, Frans L G

AU - Bloemendal, Haiko J.

AU - Koopman, Miriam

AU - de Roos, Marnix A J

AU - Verhaar, Marlies J.

AU - ten Bokkel-Huinink, Daan

AU - van der Wall, Elsken

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N2 - PURPOSE: Fatigue is a common problem among colon cancer patients and typically increases during chemotherapy. Exercise during chemotherapy might have beneficial effects on fatigue. To investigate the short- and long-term effects of an exercise program in colon cancer patients during adjuvant treatment, the Physical Activity during Cancer Treatment (PACT) study was conducted. METHODS: In this multicenter randomized controlled trial, 33 colon cancer patients undergoing chemotherapy (21 men and 12 women) were randomly assigned to either a group receiving an 18-week supervised exercise program (n=17) or to usual care (n=16). The primary outcome was fatigue as measured by the Multidimensional Fatigue Inventory (MFI) and the Fatigue Quality List (FQL). Secondary outcomes were quality of life, physical fitness, anxiety, depression, body weight and chemotherapy completion rate. Outcome assessment took place at baseline, post-intervention (18 weeks) and at 36 weeks. RESULTS: Intention-to-treat mixed linear model analyses showed that patients in the intervention group experienced significantly less physical fatigue at 18 weeks and general fatigue at 36 weeks (mean between group differences: -3.2, 95% CI -6.2; -0.2, effect size (ES)=-0.9 and -2.7, 95% CI -5.2; -0.1, ES=-0.8 respectively), and reported higher physical functioning (12.3, 95% CI 3.3; 21.4, ES=1.0) compared to patients in the usual care group. CONCLUSION: The PACT trial shows that an 18-week supervised exercise program in colon cancer patients during chemotherapy is safe and feasible. The intervention significantly reduced physical fatigue at 18 weeks and general fatigue at 36 weeks. Considering the number of patients included in the present study, replication in a larger study population is required.

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