Effects of aging on the hippocampal formation in a naturally occurring animal model of mild cognitive impairment

Michela Gallagher, Jennifer L. Bizon, Eileen C. Hoyt, Katherine A. Helm, Pauline K. Lund

Research output: Contribution to journalArticle

Abstract

Vertical integration is being used to great advantage in neurobiological research on the basis of age-related cognitive decline. Such research bridges analysis between the molecular and cellular levels and the outcome of impaired psychological functions. Current use of animals models within this paradigm has defined mild cognitive impairment in a subpopulation of outbred aged Long-Evans rats by assessment of hippocampal-dependent spatial cognition. Aged rats with cognitive impairment exhibited no loss of neurons in the hippocampus. Current research is focused on the functional alterations in neurons by methods which assess transcriptional mechanisms and signaling pathways.

Original languageEnglish (US)
Pages (from-to)71-77
Number of pages7
JournalExperimental Gerontology
Volume38
Issue number1-2
DOIs
StatePublished - Jan 2003

Fingerprint

Hippocampus
Animals
Animal Models
Aging of materials
Neurons
Rats
Research
Long Evans Rats
Cognition
Psychology
Cognitive Dysfunction

Keywords

  • Glucocorticoids
  • Hippocampus
  • NFκB
  • Rats
  • Spatial memory
  • Synaptic protein

ASJC Scopus subject areas

  • Aging
  • Medicine(all)

Cite this

Effects of aging on the hippocampal formation in a naturally occurring animal model of mild cognitive impairment. / Gallagher, Michela; Bizon, Jennifer L.; Hoyt, Eileen C.; Helm, Katherine A.; Lund, Pauline K.

In: Experimental Gerontology, Vol. 38, No. 1-2, 01.2003, p. 71-77.

Research output: Contribution to journalArticle

Gallagher, Michela ; Bizon, Jennifer L. ; Hoyt, Eileen C. ; Helm, Katherine A. ; Lund, Pauline K. / Effects of aging on the hippocampal formation in a naturally occurring animal model of mild cognitive impairment. In: Experimental Gerontology. 2003 ; Vol. 38, No. 1-2. pp. 71-77.
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