Effects of age on dopamine and serotonin receptors measured by positron tomography in the living human brain

Dean F. Wong, Henry N. Wagner, Robert F. Dannals, Jonathan M. Links, J. James Frost, Hayden T. Ravert, Alan A. Wilson, Arthur E. Rosenbaum, Albert Gjedde, Kenneth H. Douglass, John D. Petronis, Marshal F. Folstein, J. K.Thomas Toung, H. Donald Burns, Michael J. Kuhar

Research output: Contribution to journalArticle

Abstract

D2 dopamine and S2 serotonin receptors were imaged and measured in healthy human subjects by positron emission tomography after intravenous injection of 11C-labeled 3-N-methylspiperone. Levels of receptor in the caudate nucleus, putamen, and frontal cerebral cortex declined over the age span studied (19 to 73 years). The decline in D2 receptor in males was different from that in females.

Original languageEnglish (US)
Pages (from-to)1393-1396
Number of pages4
JournalScience
Volume226
Issue number4681
DOIs
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • General

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    Wong, D. F., Wagner, H. N., Dannals, R. F., Links, J. M., Frost, J. J., Ravert, H. T., Wilson, A. A., Rosenbaum, A. E., Gjedde, A., Douglass, K. H., Petronis, J. D., Folstein, M. F., Toung, J. K. T., Burns, H. D., & Kuhar, M. J. (1984). Effects of age on dopamine and serotonin receptors measured by positron tomography in the living human brain. Science, 226(4681), 1393-1396. https://doi.org/10.1126/science.6334363