Effects of age on dopamine and serotonin receptors measured by positron tomography in the living human brain

Dean Foster Wong, Henry N. Wagner, Robert F Dannals, Jonathan M Links, J. James Frost, Hayden T. Ravert, Alan A. Wilson, Arthur E. Rosenbaum, Albert Gjedde, Kenneth H. Douglass, John D. Petronis, Marshal F. Folstein, Thomas J Toung, H. Donald Burns, Michael J. Kuhar

Research output: Contribution to journalArticle

Abstract

D2 dopamine and S2 serotonin receptors were imaged and measured in healthy human subjects by positron emission tomography after intravenous injection of 11C-labeled 3-N-methylspiperone. Levels of receptor in the caudate nucleus, putamen, and frontal cerebral cortex declined over the age span studied (19 to 73 years). The decline in D2 receptor in males was different from that in females.

Original languageEnglish (US)
Pages (from-to)1393-1396
Number of pages4
JournalScience
Volume226
Issue number4681
StatePublished - 1984

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Serotonin 5-HT2 Receptors
Caudate Nucleus
Serotonin Receptors
Putamen
Dopamine Receptors
Frontal Lobe
Intravenous Injections
Positron-Emission Tomography
Cerebral Cortex
Dopamine
Healthy Volunteers
Tomography
Electrons
Brain
3-N-methylspiperone

ASJC Scopus subject areas

  • General

Cite this

Effects of age on dopamine and serotonin receptors measured by positron tomography in the living human brain. / Wong, Dean Foster; Wagner, Henry N.; Dannals, Robert F; Links, Jonathan M; Frost, J. James; Ravert, Hayden T.; Wilson, Alan A.; Rosenbaum, Arthur E.; Gjedde, Albert; Douglass, Kenneth H.; Petronis, John D.; Folstein, Marshal F.; Toung, Thomas J; Burns, H. Donald; Kuhar, Michael J.

In: Science, Vol. 226, No. 4681, 1984, p. 1393-1396.

Research output: Contribution to journalArticle

Wong, DF, Wagner, HN, Dannals, RF, Links, JM, Frost, JJ, Ravert, HT, Wilson, AA, Rosenbaum, AE, Gjedde, A, Douglass, KH, Petronis, JD, Folstein, MF, Toung, TJ, Burns, HD & Kuhar, MJ 1984, 'Effects of age on dopamine and serotonin receptors measured by positron tomography in the living human brain', Science, vol. 226, no. 4681, pp. 1393-1396.
Wong, Dean Foster ; Wagner, Henry N. ; Dannals, Robert F ; Links, Jonathan M ; Frost, J. James ; Ravert, Hayden T. ; Wilson, Alan A. ; Rosenbaum, Arthur E. ; Gjedde, Albert ; Douglass, Kenneth H. ; Petronis, John D. ; Folstein, Marshal F. ; Toung, Thomas J ; Burns, H. Donald ; Kuhar, Michael J. / Effects of age on dopamine and serotonin receptors measured by positron tomography in the living human brain. In: Science. 1984 ; Vol. 226, No. 4681. pp. 1393-1396.
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AU - Links, Jonathan M

AU - Frost, J. James

AU - Ravert, Hayden T.

AU - Wilson, Alan A.

AU - Rosenbaum, Arthur E.

AU - Gjedde, Albert

AU - Douglass, Kenneth H.

AU - Petronis, John D.

AU - Folstein, Marshal F.

AU - Toung, Thomas J

AU - Burns, H. Donald

AU - Kuhar, Michael J.

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