Effects of acute acid-base alterations on glutamine metabolism and renal ammoniagenesis in the dog

A. Fine, F. I. Bennett, G. A O Alleyne

Research output: Contribution to journalArticle

Abstract

The effects of acute acid-base alterations on renal ammonia production and glutamine metabolism were studied in anaesthetized dogs. Plasma glutamine rose with acidosis and also when both PCO2 and plasma HCO3- were raised isohydrically. Blood urea fell when acidosis was induced with hydrochloric acid. The renal production of ammonia per ml of renal blood flow was increased in acidosis, but this was independent of the amount of glutamine delivered to the kidney. The results indicate that acute acidosis affects production of urea and glutamine and increases the capacity of the renal cells to extract glutamine from blood.

Original languageEnglish (US)
Pages (from-to)503-508
Number of pages6
JournalClinical Science and Molecular Medicine
Volume54
Issue number5
StatePublished - 1978
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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