Effects of acid aspiration-induced acute lung injury on kidney function

Jeffrey B. Hoag, Manchang Liu, R. Blaine Easley, Martin F. Britos-Bray, Priya Kesari, Heitham T Hassoun, Mark Haas, Rubin M. Tuder, Hamid Rabb, Brett A. Simon

Research output: Contribution to journalArticle

Abstract

Acute lung injury (ALI) in combination with acute kidney injury carries a mortality approaching 80% in the intensive care unit. Recently, attention has focused on the interaction of the lung and kidney in the setting of ALI and mechanical ventilation (MV). Small animal models of ALI and MV have demonstrated changes in inflammatory mediators, water channels, apoptosis, and function in the kidney early in the course of injury. The purpose of this investigation was to test the hypothesis that ALI and injurious MV cause early, measurable changes in kidney structure and function in a canine HCl aspiration model of ALI when hemodynamics and arterial blood gas tensions are carefully controlled. Intratracheal HCl induced profound ALI as demonstrated by increased shunt fraction and airway pressures compared with sham injury. Shaminjured animals had similar mean arterial pressure and arterial PCO2 and HCO3 levels compared with injured animals. Measurements of renal function including renal blood flow, urine flow, serum creatinine, glomerular filtration rate, urine albumin-to-creatinine ratio, and kidney histology scores were not different between groups. With maintenance of hemodynamic parameters and alveolar ventilation, ALI and injurious MV do not alter kidney structure and function early in the course of injury in this acid aspiration canine model. Kidney injury in large animal models may be more similar to humans and may differ from results seen in small animal models.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Renal Physiology
Volume294
Issue number4
DOIs
StatePublished - Apr 2008

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Acute Lung Injury
Kidney
Acids
Artificial Respiration
Animal Models
Wounds and Injuries
Canidae
Creatinine
Hemodynamics
Urine
Aquaporins
Renal Circulation
Glomerular Filtration Rate
Acute Kidney Injury
Intensive Care Units
Ventilation
Albumins
Histology
Arterial Pressure
Gases

Keywords

  • Biotrauma
  • Mechanical ventilation
  • Renal function

ASJC Scopus subject areas

  • Physiology
  • Urology

Cite this

Hoag, J. B., Liu, M., Easley, R. B., Britos-Bray, M. F., Kesari, P., Hassoun, H. T., ... Simon, B. A. (2008). Effects of acid aspiration-induced acute lung injury on kidney function. American Journal of Physiology - Renal Physiology, 294(4). https://doi.org/10.1152/ajprenal.00357.2007

Effects of acid aspiration-induced acute lung injury on kidney function. / Hoag, Jeffrey B.; Liu, Manchang; Easley, R. Blaine; Britos-Bray, Martin F.; Kesari, Priya; Hassoun, Heitham T; Haas, Mark; Tuder, Rubin M.; Rabb, Hamid; Simon, Brett A.

In: American Journal of Physiology - Renal Physiology, Vol. 294, No. 4, 04.2008.

Research output: Contribution to journalArticle

Hoag, JB, Liu, M, Easley, RB, Britos-Bray, MF, Kesari, P, Hassoun, HT, Haas, M, Tuder, RM, Rabb, H & Simon, BA 2008, 'Effects of acid aspiration-induced acute lung injury on kidney function', American Journal of Physiology - Renal Physiology, vol. 294, no. 4. https://doi.org/10.1152/ajprenal.00357.2007
Hoag, Jeffrey B. ; Liu, Manchang ; Easley, R. Blaine ; Britos-Bray, Martin F. ; Kesari, Priya ; Hassoun, Heitham T ; Haas, Mark ; Tuder, Rubin M. ; Rabb, Hamid ; Simon, Brett A. / Effects of acid aspiration-induced acute lung injury on kidney function. In: American Journal of Physiology - Renal Physiology. 2008 ; Vol. 294, No. 4.
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