Effects of a single-dose pretreatment with captopril on the immediate response to nasal challenge with allergen

David Proud, Robert M. Naclerio, Deborah A. Meyers, Anne Kagey-Sobotka, Lawrence M. Lichtenstein, Martin D. Valentine

Research output: Contribution to journalArticle

Abstract

We performed a double-blind, placebo-controlled, crossover study using 12 subjects to determine the effects of a single 50-mg dose of captopril on the response to nasal challenge with increasing doses of allergen. Levels of kinins, histamine and N-α-p-tosyl-L-arginine methyl ester (TAME)-esterase activity were measured in nasal lavages, and symptom scores and the number of sneezes were recorded. Captopril had no significant effects on histamine, TAME-esterase, sneezing or symptom scores. Peak postchallenge kinin levels, however, were significantly elevated (p

Original languageEnglish (US)
Pages (from-to)165-170
Number of pages6
JournalInternational Archives of Allergy and Immunology
Volume93
Issue number2-3
DOIs
StatePublished - 1990

Fingerprint

Kinins
Captopril
Nose
Allergens
Histamine
Nasal Lavage
Sneezing
Esterases
Cross-Over Studies
Placebos
tosylarginine methyl ester hydrolase
arginine methyl ester

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Effects of a single-dose pretreatment with captopril on the immediate response to nasal challenge with allergen. / Proud, David; Naclerio, Robert M.; Meyers, Deborah A.; Kagey-Sobotka, Anne; Lichtenstein, Lawrence M.; Valentine, Martin D.

In: International Archives of Allergy and Immunology, Vol. 93, No. 2-3, 1990, p. 165-170.

Research output: Contribution to journalArticle

Proud, David ; Naclerio, Robert M. ; Meyers, Deborah A. ; Kagey-Sobotka, Anne ; Lichtenstein, Lawrence M. ; Valentine, Martin D. / Effects of a single-dose pretreatment with captopril on the immediate response to nasal challenge with allergen. In: International Archives of Allergy and Immunology. 1990 ; Vol. 93, No. 2-3. pp. 165-170.
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