Effects of a single-dose pretreatment with captopril on the immediate response to nasal challenge with allergen

David Proud, Robert M. Naclerio, Deborah A. Meyers, Anne Kagey-Sobotka, Lawrence M. Lichtenstein, Martin D. Valentine

Research output: Contribution to journalArticlepeer-review

Abstract

We performed a double-blind, placebo-controlled, crossover study using 12 subjects to determine the effects of a single 50-mg dose of captopril on the response to nasal challenge with increasing doses of allergen. Levels of kinins, histamine and N-α-p-tosyl-L-arginine methyl ester (TAME)-esterase activity were measured in nasal lavages, and symptom scores and the number of sneezes were recorded. Captopril had no significant effects on histamine, TAME-esterase, sneezing or symptom scores. Peak postchallenge kinin levels, however, were significantly elevated (p <0.05) compared to placebo, while an increase in the magnitude of the dose-response curve was of marginal significance (p = 0.058). Thus, captopril causes increases in the kinin levels in nasal secretions during the allergic response. If increased kinin levels persist or worsen with chronic therapy, it is possible that they could exacerbate allergic symptoms during repeated seasonal exposure.

Original languageEnglish (US)
Pages (from-to)165-170
Number of pages6
JournalInternational archives of allergy and immunology
Volume93
Issue number2-3
DOIs
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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