Effects of a novel leumedin NPC 15669 on myocardial stunning and preconditioned infarction size in swine

William R. Herzog, Paul A. Gurbel, Robert A. Vogel, Matthew L. Schlossberg, Alan I. Schneider, Victor L. Serebruany

Research output: Contribution to journalArticle

Abstract

Background: NPC is a member of the leumedins and is an inhibitor of leukocyte adhesion to endothelium via blockage of integrin binding. NPC 15669 also may have anti-platelet effects. We tested the efficacy of the novel leukocyte recruitment inhibitor NPC 15669 on myocardial stunning (MS) and preconditioned myocardial infarction (MI). Methods and Results: In an open-chested swine model, NPC 15669 (10 mg NPC/kg loading dose followed by constant infusion at 6 mg/kg/hr) was administered in six animals. Myocardial thickening (MT) was determined by epicardial ultrasound. The left anterior descending artery was occluded for 8 minutes followed by 90 minutes of reperfusion, during which myocardial MT was recorded at regular intervals. We have found that treatment with NPC 15669 increases myocardial contractility and significantly decreases MS time compared to controls (26.7±4.0 minutes vs. 50.0±4.3 minutes, p=.0026). In NPC 15669-treated animals we observed a reduction of MI size (23.4±6.7% of tissue at risk became necrotic compared to 53.0±6.6% in controls, p=.0102). Conclusions: Our data suggest that NPC 15669 significantly reduces myocardial injury in both the stunning and infarction models.

Original languageEnglish (US)
Pages (from-to)163-170
Number of pages8
JournalJournal of Thrombosis and Thrombolysis
Volume1
Issue number2
DOIs
StatePublished - Jun 1 1995

Keywords

  • NPC 15669
  • animal model
  • myocardial infarction
  • myocardial stunning

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine

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    Herzog, W. R., Gurbel, P. A., Vogel, R. A., Schlossberg, M. L., Schneider, A. I., & Serebruany, V. L. (1995). Effects of a novel leumedin NPC 15669 on myocardial stunning and preconditioned infarction size in swine. Journal of Thrombosis and Thrombolysis, 1(2), 163-170. https://doi.org/10.1007/BF01062574