Effects and mechanisms of anal electrical stimulation on anorectal compliance and tone in dogs

Yuqiang Nie, Jiande Chen

Research output: Contribution to journalArticle

Abstract

PURPOSE: This study was designed to investigate the changes in rectal compliance and tone during anal electric stimulation and the involvement of the α-adrenergic pathway in conscious dogs. METHODS: Eight healthy dogs were studied in five randomized sessions. Anal sphincter pressure was quantified by using the area under the contractile curve. Rectal compliance and tone were measured in a pressure-controlled phasic and isobaric distention by using an electronic barostat. Anal electric stimulation was performed via a pair of ring electrodes attached to the catheter. RESULTS: The electric stimulation-induced increase in sphincter pressure was lowered by the presence of an α1-adrenergic receptor antagonist, prazosin (18.6 ± 7.4 vs. 45.4 ± 9.7, P <0.05), or α2-adrenergic receptor antagonist, yohimbine (10.2 ± 8.2 vs. 38.3 ± 7.6, P <0.05), compared with the control. The threshold volume in rectoanal inhibitory reflex during electric stimulation was significantly higher than during baseline (27.5 ± 0.9 vs. 22.5 ± 1.9 ml, P <0.05). There were no significant differences between the percentage drops in sphincter pressure with and without stimulation at a rectal distention level of 45 ml of air. Anal electric stimulation significantly increased rectal compliance reflected as reduced P1/2 (11.1 ± 1.5 vs. 16.7 ± 1.1, P = 0.027) and reduced κ (11.6 ± 2.5 vs. 20.5 ± 2.6, P = 0.0095), compared with the control session, but did not significantly alter rectal tone. CONCLUSIONS: Anal electric stimulation increases anal sphincter pressure, mediated at least partially by the α-adrenergic pathway. It also increases rectal compliance but does not alter rectal anal inhibitory reflexes.

Original languageEnglish (US)
Pages (from-to)1414-1421
Number of pages8
JournalDiseases of the Colon and Rectum
Volume49
Issue number9
DOIs
StatePublished - Sep 2006
Externally publishedYes

Fingerprint

Electric Stimulation
Compliance
Dogs
Pressure
Adrenergic Antagonists
Anal Canal
Adrenergic Agents
Reflex
Yohimbine
Prazosin
Area Under Curve
Electrodes
Catheters
Air

Keywords

  • Anal sphincter
  • Anorectal motility
  • Electrical stimulation
  • Fecal incontinence
  • Rectal compliance

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Effects and mechanisms of anal electrical stimulation on anorectal compliance and tone in dogs. / Nie, Yuqiang; Chen, Jiande.

In: Diseases of the Colon and Rectum, Vol. 49, No. 9, 09.2006, p. 1414-1421.

Research output: Contribution to journalArticle

@article{1ffceb3baa6b48099249c728ed22b10c,
title = "Effects and mechanisms of anal electrical stimulation on anorectal compliance and tone in dogs",
abstract = "PURPOSE: This study was designed to investigate the changes in rectal compliance and tone during anal electric stimulation and the involvement of the α-adrenergic pathway in conscious dogs. METHODS: Eight healthy dogs were studied in five randomized sessions. Anal sphincter pressure was quantified by using the area under the contractile curve. Rectal compliance and tone were measured in a pressure-controlled phasic and isobaric distention by using an electronic barostat. Anal electric stimulation was performed via a pair of ring electrodes attached to the catheter. RESULTS: The electric stimulation-induced increase in sphincter pressure was lowered by the presence of an α1-adrenergic receptor antagonist, prazosin (18.6 ± 7.4 vs. 45.4 ± 9.7, P <0.05), or α2-adrenergic receptor antagonist, yohimbine (10.2 ± 8.2 vs. 38.3 ± 7.6, P <0.05), compared with the control. The threshold volume in rectoanal inhibitory reflex during electric stimulation was significantly higher than during baseline (27.5 ± 0.9 vs. 22.5 ± 1.9 ml, P <0.05). There were no significant differences between the percentage drops in sphincter pressure with and without stimulation at a rectal distention level of 45 ml of air. Anal electric stimulation significantly increased rectal compliance reflected as reduced P1/2 (11.1 ± 1.5 vs. 16.7 ± 1.1, P = 0.027) and reduced κ (11.6 ± 2.5 vs. 20.5 ± 2.6, P = 0.0095), compared with the control session, but did not significantly alter rectal tone. CONCLUSIONS: Anal electric stimulation increases anal sphincter pressure, mediated at least partially by the α-adrenergic pathway. It also increases rectal compliance but does not alter rectal anal inhibitory reflexes.",
keywords = "Anal sphincter, Anorectal motility, Electrical stimulation, Fecal incontinence, Rectal compliance",
author = "Yuqiang Nie and Jiande Chen",
year = "2006",
month = "9",
doi = "10.1007/s10350-006-0599-x",
language = "English (US)",
volume = "49",
pages = "1414--1421",
journal = "Diseases of the Colon and Rectum",
issn = "0012-3706",
publisher = "Lippincott Williams and Wilkins",
number = "9",

}

TY - JOUR

T1 - Effects and mechanisms of anal electrical stimulation on anorectal compliance and tone in dogs

AU - Nie, Yuqiang

AU - Chen, Jiande

PY - 2006/9

Y1 - 2006/9

N2 - PURPOSE: This study was designed to investigate the changes in rectal compliance and tone during anal electric stimulation and the involvement of the α-adrenergic pathway in conscious dogs. METHODS: Eight healthy dogs were studied in five randomized sessions. Anal sphincter pressure was quantified by using the area under the contractile curve. Rectal compliance and tone were measured in a pressure-controlled phasic and isobaric distention by using an electronic barostat. Anal electric stimulation was performed via a pair of ring electrodes attached to the catheter. RESULTS: The electric stimulation-induced increase in sphincter pressure was lowered by the presence of an α1-adrenergic receptor antagonist, prazosin (18.6 ± 7.4 vs. 45.4 ± 9.7, P <0.05), or α2-adrenergic receptor antagonist, yohimbine (10.2 ± 8.2 vs. 38.3 ± 7.6, P <0.05), compared with the control. The threshold volume in rectoanal inhibitory reflex during electric stimulation was significantly higher than during baseline (27.5 ± 0.9 vs. 22.5 ± 1.9 ml, P <0.05). There were no significant differences between the percentage drops in sphincter pressure with and without stimulation at a rectal distention level of 45 ml of air. Anal electric stimulation significantly increased rectal compliance reflected as reduced P1/2 (11.1 ± 1.5 vs. 16.7 ± 1.1, P = 0.027) and reduced κ (11.6 ± 2.5 vs. 20.5 ± 2.6, P = 0.0095), compared with the control session, but did not significantly alter rectal tone. CONCLUSIONS: Anal electric stimulation increases anal sphincter pressure, mediated at least partially by the α-adrenergic pathway. It also increases rectal compliance but does not alter rectal anal inhibitory reflexes.

AB - PURPOSE: This study was designed to investigate the changes in rectal compliance and tone during anal electric stimulation and the involvement of the α-adrenergic pathway in conscious dogs. METHODS: Eight healthy dogs were studied in five randomized sessions. Anal sphincter pressure was quantified by using the area under the contractile curve. Rectal compliance and tone were measured in a pressure-controlled phasic and isobaric distention by using an electronic barostat. Anal electric stimulation was performed via a pair of ring electrodes attached to the catheter. RESULTS: The electric stimulation-induced increase in sphincter pressure was lowered by the presence of an α1-adrenergic receptor antagonist, prazosin (18.6 ± 7.4 vs. 45.4 ± 9.7, P <0.05), or α2-adrenergic receptor antagonist, yohimbine (10.2 ± 8.2 vs. 38.3 ± 7.6, P <0.05), compared with the control. The threshold volume in rectoanal inhibitory reflex during electric stimulation was significantly higher than during baseline (27.5 ± 0.9 vs. 22.5 ± 1.9 ml, P <0.05). There were no significant differences between the percentage drops in sphincter pressure with and without stimulation at a rectal distention level of 45 ml of air. Anal electric stimulation significantly increased rectal compliance reflected as reduced P1/2 (11.1 ± 1.5 vs. 16.7 ± 1.1, P = 0.027) and reduced κ (11.6 ± 2.5 vs. 20.5 ± 2.6, P = 0.0095), compared with the control session, but did not significantly alter rectal tone. CONCLUSIONS: Anal electric stimulation increases anal sphincter pressure, mediated at least partially by the α-adrenergic pathway. It also increases rectal compliance but does not alter rectal anal inhibitory reflexes.

KW - Anal sphincter

KW - Anorectal motility

KW - Electrical stimulation

KW - Fecal incontinence

KW - Rectal compliance

UR - http://www.scopus.com/inward/record.url?scp=33748751175&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748751175&partnerID=8YFLogxK

U2 - 10.1007/s10350-006-0599-x

DO - 10.1007/s10350-006-0599-x

M3 - Article

C2 - 16826335

AN - SCOPUS:33748751175

VL - 49

SP - 1414

EP - 1421

JO - Diseases of the Colon and Rectum

JF - Diseases of the Colon and Rectum

SN - 0012-3706

IS - 9

ER -