Abstract
PURPOSE: This study was designed to investigate the changes in rectal compliance and tone during anal electric stimulation and the involvement of the α-adrenergic pathway in conscious dogs. METHODS: Eight healthy dogs were studied in five randomized sessions. Anal sphincter pressure was quantified by using the area under the contractile curve. Rectal compliance and tone were measured in a pressure-controlled phasic and isobaric distention by using an electronic barostat. Anal electric stimulation was performed via a pair of ring electrodes attached to the catheter. RESULTS: The electric stimulation-induced increase in sphincter pressure was lowered by the presence of an α1-adrenergic receptor antagonist, prazosin (18.6 ± 7.4 vs. 45.4 ± 9.7, P <0.05), or α2-adrenergic receptor antagonist, yohimbine (10.2 ± 8.2 vs. 38.3 ± 7.6, P <0.05), compared with the control. The threshold volume in rectoanal inhibitory reflex during electric stimulation was significantly higher than during baseline (27.5 ± 0.9 vs. 22.5 ± 1.9 ml, P <0.05). There were no significant differences between the percentage drops in sphincter pressure with and without stimulation at a rectal distention level of 45 ml of air. Anal electric stimulation significantly increased rectal compliance reflected as reduced P1/2 (11.1 ± 1.5 vs. 16.7 ± 1.1, P = 0.027) and reduced κ (11.6 ± 2.5 vs. 20.5 ± 2.6, P = 0.0095), compared with the control session, but did not significantly alter rectal tone. CONCLUSIONS: Anal electric stimulation increases anal sphincter pressure, mediated at least partially by the α-adrenergic pathway. It also increases rectal compliance but does not alter rectal anal inhibitory reflexes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1414-1421 |
| Number of pages | 8 |
| Journal | Diseases of the Colon and Rectum |
| Volume | 49 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 2006 |
| Externally published | Yes |
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Keywords
- Anal sphincter
- Anorectal motility
- Electrical stimulation
- Fecal incontinence
- Rectal compliance
ASJC Scopus subject areas
- Gastroenterology
Cite this
Effects and mechanisms of anal electrical stimulation on anorectal compliance and tone in dogs. / Nie, Yuqiang; Chen, Jiande.
In: Diseases of the Colon and Rectum, Vol. 49, No. 9, 09.2006, p. 1414-1421.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects and mechanisms of anal electrical stimulation on anorectal compliance and tone in dogs
AU - Nie, Yuqiang
AU - Chen, Jiande
PY - 2006/9
Y1 - 2006/9
N2 - PURPOSE: This study was designed to investigate the changes in rectal compliance and tone during anal electric stimulation and the involvement of the α-adrenergic pathway in conscious dogs. METHODS: Eight healthy dogs were studied in five randomized sessions. Anal sphincter pressure was quantified by using the area under the contractile curve. Rectal compliance and tone were measured in a pressure-controlled phasic and isobaric distention by using an electronic barostat. Anal electric stimulation was performed via a pair of ring electrodes attached to the catheter. RESULTS: The electric stimulation-induced increase in sphincter pressure was lowered by the presence of an α1-adrenergic receptor antagonist, prazosin (18.6 ± 7.4 vs. 45.4 ± 9.7, P <0.05), or α2-adrenergic receptor antagonist, yohimbine (10.2 ± 8.2 vs. 38.3 ± 7.6, P <0.05), compared with the control. The threshold volume in rectoanal inhibitory reflex during electric stimulation was significantly higher than during baseline (27.5 ± 0.9 vs. 22.5 ± 1.9 ml, P <0.05). There were no significant differences between the percentage drops in sphincter pressure with and without stimulation at a rectal distention level of 45 ml of air. Anal electric stimulation significantly increased rectal compliance reflected as reduced P1/2 (11.1 ± 1.5 vs. 16.7 ± 1.1, P = 0.027) and reduced κ (11.6 ± 2.5 vs. 20.5 ± 2.6, P = 0.0095), compared with the control session, but did not significantly alter rectal tone. CONCLUSIONS: Anal electric stimulation increases anal sphincter pressure, mediated at least partially by the α-adrenergic pathway. It also increases rectal compliance but does not alter rectal anal inhibitory reflexes.
AB - PURPOSE: This study was designed to investigate the changes in rectal compliance and tone during anal electric stimulation and the involvement of the α-adrenergic pathway in conscious dogs. METHODS: Eight healthy dogs were studied in five randomized sessions. Anal sphincter pressure was quantified by using the area under the contractile curve. Rectal compliance and tone were measured in a pressure-controlled phasic and isobaric distention by using an electronic barostat. Anal electric stimulation was performed via a pair of ring electrodes attached to the catheter. RESULTS: The electric stimulation-induced increase in sphincter pressure was lowered by the presence of an α1-adrenergic receptor antagonist, prazosin (18.6 ± 7.4 vs. 45.4 ± 9.7, P <0.05), or α2-adrenergic receptor antagonist, yohimbine (10.2 ± 8.2 vs. 38.3 ± 7.6, P <0.05), compared with the control. The threshold volume in rectoanal inhibitory reflex during electric stimulation was significantly higher than during baseline (27.5 ± 0.9 vs. 22.5 ± 1.9 ml, P <0.05). There were no significant differences between the percentage drops in sphincter pressure with and without stimulation at a rectal distention level of 45 ml of air. Anal electric stimulation significantly increased rectal compliance reflected as reduced P1/2 (11.1 ± 1.5 vs. 16.7 ± 1.1, P = 0.027) and reduced κ (11.6 ± 2.5 vs. 20.5 ± 2.6, P = 0.0095), compared with the control session, but did not significantly alter rectal tone. CONCLUSIONS: Anal electric stimulation increases anal sphincter pressure, mediated at least partially by the α-adrenergic pathway. It also increases rectal compliance but does not alter rectal anal inhibitory reflexes.
KW - Anal sphincter
KW - Anorectal motility
KW - Electrical stimulation
KW - Fecal incontinence
KW - Rectal compliance
UR - http://www.scopus.com/inward/record.url?scp=33748751175&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33748751175&partnerID=8YFLogxK
U2 - 10.1007/s10350-006-0599-x
DO - 10.1007/s10350-006-0599-x
M3 - Article
C2 - 16826335
AN - SCOPUS:33748751175
VL - 49
SP - 1414
EP - 1421
JO - Diseases of the Colon and Rectum
JF - Diseases of the Colon and Rectum
SN - 0012-3706
IS - 9
ER -