Effector lymphocyte-induced lymph node-like vasculature enables naive T-cell entry into tumours and enhanced anti-tumour immunity

J. David Peske, Elizabeth Thompson, Lelisa Gemta, Richard A. Baylis, Yang Xin Fu, Victor H. Engelhard

Research output: Contribution to journalArticle

Abstract

The presence of lymph node (LN)-like vasculature in tumours, characterized by expression of peripheral node addressin and chemokine CCL21, is correlated with T-cell infiltration and positive prognosis in breast cancer and melanoma patients. However, mechanisms controlling the development of LN-like vasculature and how it might contribute to a beneficial outcome for cancer patients are unknown. Here we demonstrate that LN-like vasculature is present in murine models of melanoma and lung carcinoma. It enables infiltration by naive T cells that significantly delay tumour outgrowth after intratumoral activation. Development of this vasculature is controlled by a mechanism involving effector CD8 T cells and NK cells that secrete LTα3 and IFNγ. LN-like vasculature is also associated with organized aggregates of B lymphocytes and gp38+ fibroblasts, which resemble tertiary lymphoid organs that develop in models of chronic inflammation. These results establish LN-like vasculature as both a consequence of and key contributor to anti-tumour immunity.

Original languageEnglish (US)
Article number7114
JournalNature Communications
Volume6
DOIs
StatePublished - May 13 2015

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effectors
T-cells
Lymphocytes
lymphatic system
lymphocytes
immunity
entry
Tumors
Immunity
tumors
Lymph Nodes
T-Lymphocytes
Infiltration
Chemokine CCL21
cancer
infiltration
Neoplasms
Fibroblasts
Melanoma
Chemical activation

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Effector lymphocyte-induced lymph node-like vasculature enables naive T-cell entry into tumours and enhanced anti-tumour immunity. / Peske, J. David; Thompson, Elizabeth; Gemta, Lelisa; Baylis, Richard A.; Fu, Yang Xin; Engelhard, Victor H.

In: Nature Communications, Vol. 6, 7114, 13.05.2015.

Research output: Contribution to journalArticle

Peske, J. David ; Thompson, Elizabeth ; Gemta, Lelisa ; Baylis, Richard A. ; Fu, Yang Xin ; Engelhard, Victor H. / Effector lymphocyte-induced lymph node-like vasculature enables naive T-cell entry into tumours and enhanced anti-tumour immunity. In: Nature Communications. 2015 ; Vol. 6.
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