Effectiveness, safety, and pharmacokinetics of quetiapine in aggressive children with conduct disorder

Robert L Findling, Michael D. Reed, Mary Ann O'Riordan, Christine A. Demeter, Robert J. Stansbrey, Nora K. McNamara

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To provide an initial description of the effectiveness and pharmacokinetics (PK) of quetiapine in aggressive children with conduct disorder (CD). METHOD: This 8-week, open-label outpatient trial, enrolled patients ages 6 to 12 years with CD. Outcome measures included the Rating of Aggression Against People and/or Property Scale (RAAPPS), Nisonger Child Behavior Rating Form (NCBRF), and the Conners Parent Rating Scale (CPRS-48). Blood sampling for PK analyses occurred at the end of weeks 2 and 8. RESULTS: Seventeen children (16 boys, mean age 8.9 years) were treated. The mean dose at week 8 was 4.4 mg/kg (SD = 1.1 mg/kg). Significant decreases in the baseline scores of the RAAPPS, and several subscales of the NCBRF and the CPRS were found by the end of the study (p

Original languageEnglish (US)
Pages (from-to)792-800
Number of pages9
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume45
Issue number7
DOIs
Publication statusPublished - Jul 2006
Externally publishedYes

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Keywords

  • Aggression
  • Children
  • Conduct disorder
  • Pharmacokinetics
  • Quetiapine

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Developmental and Educational Psychology

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