Effectiveness of rifampin, rifabutin, and rifapentine for preventive therapy of tuberculosis in mice

B. Ji, C. Truffot-Pernot, C. Lacroix, M. C. Raviglione, R. J. O'Brien, P. Olliaro, G. Roscigno, J. Grosset

Research output: Contribution to journalArticle

Abstract

To identify alternative regimens for preventive therapy of tuberculosis, the pharmacokinetics and antimicrobial activities of rifampin (RMP), rifabutin (RBT), and rifapentine (RPT) were compared in BCG-vaccinated and M. tuberculosis-infected immunocompetent mice. RPT showed the highest serum peak level (Cmax) and the longest half-life (t( 1/2 )), whereas RBT displayed the lowest Cmax and the shortest t( 1/2 ). On weight-to-weight basis, both RPT and RBT were more bactericidal than RMP. The activity of RMP was significantly reduced when the frequency of administration was reduced from six to three times weekly, whereas significant bactericidal activity was still observed in mice treated with RPT, 10 mg/kg up to once fortnightly, or RBT, 10 mg/kg twice weekly. Because the bactericidal activity of RBT, 10 mg/kg six times/wk for 6 wk, or RPT, 10 mg/kg two times/wk for 12 wk, was comparable to that of RMP, 10 mg/kg six times/wk for 12 wk in mice, the two regimens are appropriate for clinical trials of preventive therapy of tuberculosis.

Original languageEnglish (US)
Pages (from-to)1541-1546
Number of pages6
JournalAmerican Review of Respiratory Disease
Volume148
Issue number6 I
StatePublished - Dec 1 1993

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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    Ji, B., Truffot-Pernot, C., Lacroix, C., Raviglione, M. C., O'Brien, R. J., Olliaro, P., Roscigno, G., & Grosset, J. (1993). Effectiveness of rifampin, rifabutin, and rifapentine for preventive therapy of tuberculosis in mice. American Review of Respiratory Disease, 148(6 I), 1541-1546.