Effectiveness of once-weekly rifapentine and moxifloxacin regimens against Mycobacterium tuberculosis in mice

N. Lounis, A. Bentoucha, C. Trufoot-Pernot, B. Ji, R. J. O'Brein, A. Vernon, G. Roscigno, J. Grosset

Research output: Contribution to journalArticle

Abstract

Mice infected with 1.6 x 107 CFU of Mycobacterium tuberculosis were treated 14 days later for 6 months with a regimen of once-weekly 10 mg of rifapentine and 75 mg of isoniazid per kg of body weight supplemented with either 150 mg of streptomycin per kg or 100 mg of moxifloxacin per kg during either both the 2-week daily initial and once-weekly continuation phases or only in the daily 2-week initial phase. On completion of treatment, all lung cultures were negative, except for three mice, each with a single colony: two whose rifapentine-isoniazid regimen was supplemented with streptomycin during the whole course of therapy and one whose rifapentine-isoniazid regimen had no initial daily phase, but was supplemented with streptomycin and moxifloxacin during the whole course of therapy. After 3 months of follow-up, positive lung cultures were obtained from 61 and 56% of mice supplemented with streptomycin during either the full course of therapy or only the daily 2-week initial phase, respectively, and 15 and 50% of mice supplemented with moxifloxacin during either the full course of therapy or only the daily 2-week initial phase, respectively. These results suggest that moxifloxacin has sterilizing activity against M. tuberculosis.

Original languageEnglish (US)
Pages (from-to)3482-3486
Number of pages5
JournalAntimicrobial agents and chemotherapy
Volume45
Issue number12
DOIs
StatePublished - Dec 13 2001

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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    Lounis, N., Bentoucha, A., Trufoot-Pernot, C., Ji, B., O'Brein, R. J., Vernon, A., Roscigno, G., & Grosset, J. (2001). Effectiveness of once-weekly rifapentine and moxifloxacin regimens against Mycobacterium tuberculosis in mice. Antimicrobial agents and chemotherapy, 45(12), 3482-3486. https://doi.org/10.1128/AAC.45.12.3482-3486.2001