Abstract
Limited pharmacological options are available for management pediatric hypertriglyceridemia. We examined the effectiveness of dietary fish oil supplementation as a means to reduce triglyceride levels in pediatric patients. We reviewed 111 children aged 8 to 18 years with hypertriglyceridemia (1.5 mmol/L) undergoing treatment in a specialized dyslipidemia clinic. At the treating cardiologist's discretion, 60 subjects received nonprescription fish oil supplementation (500-1000 mg/d), while the remaining patients did not. Initially there were no baseline differences between groups, including the use of concomitant lipid-lowering medication. Treatment with fish oil was associated with a potential clinically relevant but non-statistically significant decrease in triglycerides and triglyceride-to-high-density lipoprotein (HDL) ratio. Fish oil had no effect on HDL-cholesterol, non-HDL-cholesterol, or total cholesterol. All associations remained unchanged when adjusted for body mass index z score, nutrition, physical activity, and screen time. Fish oil supplementation was not significantly effective in treating hypertriglyceridemia in pediatric patients.
Original language | English (US) |
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Pages (from-to) | 645-651 |
Number of pages | 7 |
Journal | Clinical pediatrics |
Volume | 53 |
Issue number | 7 |
DOIs | |
State | Published - Jun 2014 |
Externally published | Yes |
Keywords
- dyslipidemia
- fish oil
- pediatrics
- treatment
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health