Effectiveness of first-line antiretroviral therapy and acquired drug resistance among HIV-1-infected children in India

Anita Shet, Ujjwal Neogi, Pravat Nalini Sahoo, Ayesha De Costa

Research output: Contribution to journalArticle

Abstract

Analysis of treatment response among HIV-infected children in India on first-line antiretroviral treatment for >2 years revealed that 85% were virologically suppressed. Of those with virologie failure, only 17% manifested immunologic failure, whereas majority had resistance-associated mutations. The presence of resistance highlights the need for virologie monitoring of children receiving antiretroviral treatment to optimize treatment success and preserve future treatment options.

Original languageEnglish (US)
JournalPediatric Infectious Disease Journal
Volume32
Issue number5
DOIs
StatePublished - 2013
Externally publishedYes

Fingerprint

Drug Resistance
HIV-1
India
Therapeutics
HIV
Mutation

Keywords

  • Drug resistance
  • Effectiveness
  • Pediatric antiretroviral treatment
  • Virological failure

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Effectiveness of first-line antiretroviral therapy and acquired drug resistance among HIV-1-infected children in India. / Shet, Anita; Neogi, Ujjwal; Sahoo, Pravat Nalini; De Costa, Ayesha.

In: Pediatric Infectious Disease Journal, Vol. 32, No. 5, 2013.

Research output: Contribution to journalArticle

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