EFFECTIVENESS OF DIFFERENT MONITORING MODALITIES IN THE DETECTION OF NEOVASCULAR AGE-RELATED MACULAR DEGENERATION: The Home Study, Report Number 3

The AREDS2-HOME Study Research Group

Research output: Contribution to journalArticle

Abstract

PURPOSE:: To determine the effectiveness of different monitoring modalities to detect incident neovascularization associated with age-related macular degeneration (AMD). METHODS:: Secondary analyses compared the rates of detecting incident neovascular AMD in prescheduled office visits versus office visits triggered by monitoring device or by symptom realization in a randomized trial evaluating home telemonitoring device plus standard care (device arm) versus standard care alone. RESULTS:: At prescheduled office visits, neovascular AMD was detected in 14/1927 visits (0.7%, 95% confidence interval [CI]: 0.4%–1.1%) and 14/1949 visits (0.7%, 95% CI: 0.3%–1.1%) in the device and standard care alone arms, respectively. Thirty-seven participants with neovascular AMD were detected in 318 office visits (11.6%, 95% CI: 8.1%–15.2%) triggered by device or symptom realization and 17 neovascular AMD in 65 office visits (26%, 95% CI: 15.5%–36.8%) triggered by symptom realization in the device and standard care alone arms, respectively. The home device strategy had a higher neovascular-AMD detection rate than prescheduled office visits (relative risk = 16.0 [95% CI: 8.8–29.3]). Neovascular AMD detected at triggered visits were associated with less vision loss from baseline in the device arm versus standard care alone arm (−3 letters vs. −11.5 letters, respectively, P = 0.03). CONCLUSION:: Telemonitoring may alter the management of patients with AMD and improve vision outcomes.

Original languageEnglish (US)
JournalRetina
DOIs
StateAccepted/In press - May 27 2016

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Macular Degeneration
Office Visits
Equipment and Supplies
Confidence Intervals

ASJC Scopus subject areas

  • Ophthalmology

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EFFECTIVENESS OF DIFFERENT MONITORING MODALITIES IN THE DETECTION OF NEOVASCULAR AGE-RELATED MACULAR DEGENERATION : The Home Study, Report Number 3. / The AREDS2-HOME Study Research Group.

In: Retina, 27.05.2016.

Research output: Contribution to journalArticle

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title = "EFFECTIVENESS OF DIFFERENT MONITORING MODALITIES IN THE DETECTION OF NEOVASCULAR AGE-RELATED MACULAR DEGENERATION: The Home Study, Report Number 3",
abstract = "PURPOSE:: To determine the effectiveness of different monitoring modalities to detect incident neovascularization associated with age-related macular degeneration (AMD). METHODS:: Secondary analyses compared the rates of detecting incident neovascular AMD in prescheduled office visits versus office visits triggered by monitoring device or by symptom realization in a randomized trial evaluating home telemonitoring device plus standard care (device arm) versus standard care alone. RESULTS:: At prescheduled office visits, neovascular AMD was detected in 14/1927 visits (0.7{\%}, 95{\%} confidence interval [CI]: 0.4{\%}–1.1{\%}) and 14/1949 visits (0.7{\%}, 95{\%} CI: 0.3{\%}–1.1{\%}) in the device and standard care alone arms, respectively. Thirty-seven participants with neovascular AMD were detected in 318 office visits (11.6{\%}, 95{\%} CI: 8.1{\%}–15.2{\%}) triggered by device or symptom realization and 17 neovascular AMD in 65 office visits (26{\%}, 95{\%} CI: 15.5{\%}–36.8{\%}) triggered by symptom realization in the device and standard care alone arms, respectively. The home device strategy had a higher neovascular-AMD detection rate than prescheduled office visits (relative risk = 16.0 [95{\%} CI: 8.8–29.3]). Neovascular AMD detected at triggered visits were associated with less vision loss from baseline in the device arm versus standard care alone arm (−3 letters vs. −11.5 letters, respectively, P = 0.03). CONCLUSION:: Telemonitoring may alter the management of patients with AMD and improve vision outcomes.",
author = "{The AREDS2-HOME Study Research Group} and Chew, {Emily Y.} and Clemons, {Traci E.} and Molly Harrington and Bressler, {Susan B} and Elman, {Michael J.} and Kim, {Judy E.} and Richard Garfinkel and Heier, {Jeffrey S.} and Alexander Brucker and David Boyer",
year = "2016",
month = "5",
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T1 - EFFECTIVENESS OF DIFFERENT MONITORING MODALITIES IN THE DETECTION OF NEOVASCULAR AGE-RELATED MACULAR DEGENERATION

T2 - The Home Study, Report Number 3

AU - The AREDS2-HOME Study Research Group

AU - Chew, Emily Y.

AU - Clemons, Traci E.

AU - Harrington, Molly

AU - Bressler, Susan B

AU - Elman, Michael J.

AU - Kim, Judy E.

AU - Garfinkel, Richard

AU - Heier, Jeffrey S.

AU - Brucker, Alexander

AU - Boyer, David

PY - 2016/5/27

Y1 - 2016/5/27

N2 - PURPOSE:: To determine the effectiveness of different monitoring modalities to detect incident neovascularization associated with age-related macular degeneration (AMD). METHODS:: Secondary analyses compared the rates of detecting incident neovascular AMD in prescheduled office visits versus office visits triggered by monitoring device or by symptom realization in a randomized trial evaluating home telemonitoring device plus standard care (device arm) versus standard care alone. RESULTS:: At prescheduled office visits, neovascular AMD was detected in 14/1927 visits (0.7%, 95% confidence interval [CI]: 0.4%–1.1%) and 14/1949 visits (0.7%, 95% CI: 0.3%–1.1%) in the device and standard care alone arms, respectively. Thirty-seven participants with neovascular AMD were detected in 318 office visits (11.6%, 95% CI: 8.1%–15.2%) triggered by device or symptom realization and 17 neovascular AMD in 65 office visits (26%, 95% CI: 15.5%–36.8%) triggered by symptom realization in the device and standard care alone arms, respectively. The home device strategy had a higher neovascular-AMD detection rate than prescheduled office visits (relative risk = 16.0 [95% CI: 8.8–29.3]). Neovascular AMD detected at triggered visits were associated with less vision loss from baseline in the device arm versus standard care alone arm (−3 letters vs. −11.5 letters, respectively, P = 0.03). CONCLUSION:: Telemonitoring may alter the management of patients with AMD and improve vision outcomes.

AB - PURPOSE:: To determine the effectiveness of different monitoring modalities to detect incident neovascularization associated with age-related macular degeneration (AMD). METHODS:: Secondary analyses compared the rates of detecting incident neovascular AMD in prescheduled office visits versus office visits triggered by monitoring device or by symptom realization in a randomized trial evaluating home telemonitoring device plus standard care (device arm) versus standard care alone. RESULTS:: At prescheduled office visits, neovascular AMD was detected in 14/1927 visits (0.7%, 95% confidence interval [CI]: 0.4%–1.1%) and 14/1949 visits (0.7%, 95% CI: 0.3%–1.1%) in the device and standard care alone arms, respectively. Thirty-seven participants with neovascular AMD were detected in 318 office visits (11.6%, 95% CI: 8.1%–15.2%) triggered by device or symptom realization and 17 neovascular AMD in 65 office visits (26%, 95% CI: 15.5%–36.8%) triggered by symptom realization in the device and standard care alone arms, respectively. The home device strategy had a higher neovascular-AMD detection rate than prescheduled office visits (relative risk = 16.0 [95% CI: 8.8–29.3]). Neovascular AMD detected at triggered visits were associated with less vision loss from baseline in the device arm versus standard care alone arm (−3 letters vs. −11.5 letters, respectively, P = 0.03). CONCLUSION:: Telemonitoring may alter the management of patients with AMD and improve vision outcomes.

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DO - 10.1097/IAE.0000000000000940

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