Effectiveness of a household water, sanitation and hygiene package on an outpatient program for severe acute malnutrition: A pragmatic cluster-randomized controlled trial in Chad

Mathias Altmann, Chiara Altare, Nanette Van Der Spek, Jean Christophe Barbiche, Jovana Dodos, Mahamat Bechir, Myriam Ait Aissa, Patrick Kolsteren

Research output: Contribution to journalArticle

Abstract

Water, sanitation and hygiene (WASH) interventions have a small but measurable benefit on stunting, but not on wasting. Our objective was to assess the effectiveness of a household WASH package on the performance of an Outpatient Therapeutic feeding Program (OTP) for severe acute malnutrition (SAM). We conducted a cluster-randomized controlled trial embedded in a routine OTP. The study population included 20 health centers (clusters) from Mao and Mondo districts in Chad. Both arms received the OTP. The intervention arm received an additional household WASH package (chlorine, soap, water storage container, and promotion on its use). The primary objective measures were the relapse rates toSAMat 2 and 6 months post-recovery. The secondary objectives included the recovery rate from SAM,the time-to-recovery, the weight gain, and the diarrhea longitudinal prevalence in OTP. The study lasted from April 2015 to May 2016. Among the 1,603 recruited children, 845 were in the intervention arm and 758 in the control arm. No differences in the relapse rates were noticed at 2 (-0.4%; P = 0.911) and 6 (-1.0%; P = 0.532) months. The intervention decreased the time-to-recovery (-4.4 days; P = 0.038), improved the recovery rate (10.5%; P = 0.034), and the absolute weight gain (3.0 g/d; P = 0.014). No statistical differences were noticed for the diarrhea longitudinal prevalence (-1.7%; P = 0.223) and the weight gain velocity (0.4 g/kg/d; P = 0.086). Our results showed that adding a householdWASHpackage did not decrease post-recovery relapse rates but increased the recovery rate among children admitted in OTP. We recommend further robust trials in other settings to confirm our results.

Original languageEnglish (US)
Pages (from-to)1005-1012
Number of pages8
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume98
Issue number4
DOIs
StatePublished - 2018

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

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