Abstract
OBJECTIVE: To determine if isoniazid- and/or rifampicin-free antituberculosis treatment regimens are safe and effective and to identify any factors that might require changes in the regimens. PATIENTS AND METHODS: We carried out a retrospective study of patients treated with isoniazid- and/or rifampicin-free regimens between 1995 and 2005 at 2 specialized hospitals in Barcelona, Spain. Predictive factors were studied by logistic regression and the odds ratio; 95% confidence intervals were calculated. RESULTS: Eighty-five patients were included in the study: 35% were immigrants and 34% were infected with human immunodeficiency virus. The reason for omitting isoniazid or rifampicin was toxicity (53%), followed by multidrug resistance (39%). Rifampicin-free regimens were most common (42%). A change in the isoniazid- and/or rifampicin-free regimen was required in 30% of cases, but was not associated with being an immigrant. The rate of toxicity with these regimens was higher (36%), although progress was always satisfactory. Clinical course was satisfactory in 77% of patients and they were discharged. CONCLUSIONS: Isoniazid- and/or rifampicin-free regimens with adequate follow-up showed similar treatment outcomes compared with standardized treatment regimens. Although these regimens were more toxic, patient progress was good.
Original language | English (US) |
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Pages (from-to) | 478-483 |
Number of pages | 6 |
Journal | Archivos de Bronconeumologia |
Volume | 44 |
Issue number | 9 |
DOIs | |
State | Published - Sep 2008 |
Externally published | Yes |
Keywords
- Antituberculosis drugs
- Drug resistance
- Drug toxicity
- Mycobacterium tuberculosis
- Tuberculosis
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine