Effectiveness and safety of oral HIV pre-exposure prophylaxis (PrEP) for all populations: A systematic review and meta-analysis

Virginia A. Fonner, Sarah L. Dalglish, Caitlin E Kennedy, Rachel Baggaley, Kevin R. O’reilly, Florence M. Koechlin, Michelle Rodolph, Ioannis Hodges-Mameletzis, Robert M. Grant

Research output: Contribution to journalArticle

Abstract

OBJECTIVE:: Pre-exposure prophylaxis (PrEP) offers a promising new approach to HIV prevention. This systematic review and meta-analysis evaluated the evidence for use of oral PrEP containing tenofovir disoproxil fumarate (TDF) as an additional HIV prevention strategy in populations at substantial risk for HIV based on HIV acquisition, adverse events, drug resistance, sexual behavior, and reproductive health outcomes. DESIGN:: Rigorous systematic review and meta-analysis. METHODS:: A comprehensive search strategy reviewed three electronic databases and conference abstracts through April 2015. Pooled effect estimates were calculated using random-effects meta-analysis. RESULTS:: Eighteen studies were included, comprising data from 39 articles and six conference abstracts. Across populations and PrEP regimens, PrEP significantly reduced the risk of HIV acquisition compared to placebo. Trials with PrEP use >70% demonstrated the highest PrEP effectiveness (RR?=?0.30, 95% CI: 0.21–0.45, p?

Original languageEnglish (US)
JournalAIDS
DOIs
Publication statusAccepted/In press - May 5 2016

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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