Effect on Postpartum Hemorrhage of Prophylactic Oxytocin (10 IU) by Injection by Community Health Officers in Ghana

A Community-Based, Cluster-Randomized Trial

Cynthia K. Stanton, Samuel Newton, Luke C Mullany, Patience Cofie, Charlotte Tawiah Agyemang, Edward Adiibokah, Seeba Amenga-Etego, Niamh Darcy, Sadaf Khan, Deborah Armbruster, John Gyapong, Seth Owusu-Agyei

Research output: Contribution to journalArticle

Abstract

Background:Oxytocin (10 IU) is the drug of choice for prevention of postpartum hemorrhage (PPH). Its use has generally been restricted to medically trained staff in health facilities. We assessed the effectiveness, safety, and feasibility of PPH prevention using oxytocin injected by peripheral health care providers without midwifery skills at home births.Methods and Findings:This community-based, cluster-randomized trial was conducted in four rural districts in Ghana. We randomly allocated 54 community health officers (stratified on district and catchment area distance to a health facility: ≥10 km versus

Original languageEnglish (US)
Article numbere1001524
JournalPLoS Medicine
Volume10
Issue number10
DOIs
StatePublished - 2013

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Postpartum Hemorrhage
Ghana
Health Facilities
Oxytocin
Injections
Health
Midwifery
Health Personnel
Parturition
Safety
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Effect on Postpartum Hemorrhage of Prophylactic Oxytocin (10 IU) by Injection by Community Health Officers in Ghana : A Community-Based, Cluster-Randomized Trial. / Stanton, Cynthia K.; Newton, Samuel; Mullany, Luke C; Cofie, Patience; Tawiah Agyemang, Charlotte; Adiibokah, Edward; Amenga-Etego, Seeba; Darcy, Niamh; Khan, Sadaf; Armbruster, Deborah; Gyapong, John; Owusu-Agyei, Seth.

In: PLoS Medicine, Vol. 10, No. 10, e1001524, 2013.

Research output: Contribution to journalArticle

Stanton, CK, Newton, S, Mullany, LC, Cofie, P, Tawiah Agyemang, C, Adiibokah, E, Amenga-Etego, S, Darcy, N, Khan, S, Armbruster, D, Gyapong, J & Owusu-Agyei, S 2013, 'Effect on Postpartum Hemorrhage of Prophylactic Oxytocin (10 IU) by Injection by Community Health Officers in Ghana: A Community-Based, Cluster-Randomized Trial', PLoS Medicine, vol. 10, no. 10, e1001524. https://doi.org/10.1371/journal.pmed.1001524
Stanton, Cynthia K. ; Newton, Samuel ; Mullany, Luke C ; Cofie, Patience ; Tawiah Agyemang, Charlotte ; Adiibokah, Edward ; Amenga-Etego, Seeba ; Darcy, Niamh ; Khan, Sadaf ; Armbruster, Deborah ; Gyapong, John ; Owusu-Agyei, Seth. / Effect on Postpartum Hemorrhage of Prophylactic Oxytocin (10 IU) by Injection by Community Health Officers in Ghana : A Community-Based, Cluster-Randomized Trial. In: PLoS Medicine. 2013 ; Vol. 10, No. 10.
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