Effect of zinc on cadmium influx and toxicity in cultured CHO cells

P C Huang, Betty Smith, Patricia Bohdan, Alice Corrigan

Research output: Contribution to journalArticle

Abstract

Addition of zinc lowers the toxicity level of cadmium in cultured CHO cells. Cell survival and protein synthesis were used to measure the cellular toxicity of cadmium.109Cd was used to measure cadmium uptake by the cells. The results suggest that these class IIB transition metals, zinc and cadmium, share a common transport mechanism. Thus, the antagonism appears to involve a reduction in the influx of cadmium due to the presence of zinc.

Original languageEnglish (US)
Pages (from-to)211-220
Number of pages10
JournalBiological Trace Element Research
Volume2
Issue number3
DOIs
StatePublished - Sep 1980

Fingerprint

CHO Cells
Cadmium
Toxicity
Zinc
Cultured Cells
Transition metals
Cell Survival
Metals
Cells
Proteins

Keywords

  • antagonism, between zinc and cadmium in CHO cells
  • Cadmium, influx and zinc in CHO cells
  • CHO cells, zinc and cadmium in
  • metallothionein, and zinc/cadmium toxicity in CHO cells
  • toxicity and zinc in CHO cells
  • transport, of zinc and cadmium in CHO cells
  • zinc, and cadmium influx and toxicity in CHO cells

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry, medical
  • Inorganic Chemistry
  • Clinical Biochemistry
  • Biochemistry

Cite this

Effect of zinc on cadmium influx and toxicity in cultured CHO cells. / Huang, P C; Smith, Betty; Bohdan, Patricia; Corrigan, Alice.

In: Biological Trace Element Research, Vol. 2, No. 3, 09.1980, p. 211-220.

Research output: Contribution to journalArticle

Huang, P C ; Smith, Betty ; Bohdan, Patricia ; Corrigan, Alice. / Effect of zinc on cadmium influx and toxicity in cultured CHO cells. In: Biological Trace Element Research. 1980 ; Vol. 2, No. 3. pp. 211-220.
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