Effect of zinc on cadmium influx and toxicity in cultured CHO cells

P. C. Huang, Betty Smith, Patricia Bohdan, Alice Corrigan

Research output: Contribution to journalArticlepeer-review

Abstract

Addition of zinc lowers the toxicity level of cadmium in cultured CHO cells. Cell survival and protein synthesis were used to measure the cellular toxicity of cadmium.109Cd was used to measure cadmium uptake by the cells. The results suggest that these class IIB transition metals, zinc and cadmium, share a common transport mechanism. Thus, the antagonism appears to involve a reduction in the influx of cadmium due to the presence of zinc.

Original languageEnglish (US)
Pages (from-to)211-220
Number of pages10
JournalBiological Trace Element Research
Volume2
Issue number3
DOIs
StatePublished - Sep 1 1980

Keywords

  • CHO cells, zinc and cadmium in
  • Cadmium, influx and zinc in CHO cells
  • antagonism, between zinc and cadmium in CHO cells
  • metallothionein, and zinc/cadmium toxicity in CHO cells
  • toxicity and zinc in CHO cells
  • transport, of zinc and cadmium in CHO cells
  • zinc, and cadmium influx and toxicity in CHO cells

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical
  • Inorganic Chemistry

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