Effect of zinc on cadmium influx and toxicity in cultured CHO cells

P. C. Huang; Betty Smith; Patricia Bohdan; Alice Corrigan

doi:10.1007/BF02785356

Effect of zinc on cadmium influx and toxicity in cultured CHO cells

P. C. Huang, Betty Smith, Patricia Bohdan, Alice Corrigan

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Addition of zinc lowers the toxicity level of cadmium in cultured CHO cells. Cell survival and protein synthesis were used to measure the cellular toxicity of cadmium.¹⁰⁹Cd was used to measure cadmium uptake by the cells. The results suggest that these class IIB transition metals, zinc and cadmium, share a common transport mechanism. Thus, the antagonism appears to involve a reduction in the influx of cadmium due to the presence of zinc.

Original language	English (US)
Pages (from-to)	211-220
Number of pages	10
Journal	Biological Trace Element Research
Volume	2
Issue number	3
DOIs	https://doi.org/10.1007/BF02785356
State	Published - Sep 1 1980

Keywords

CHO cells, zinc and cadmium in
Cadmium, influx and zinc in CHO cells
antagonism, between zinc and cadmium in CHO cells
metallothionein, and zinc/cadmium toxicity in CHO cells
toxicity and zinc in CHO cells
transport, of zinc and cadmium in CHO cells
zinc, and cadmium influx and toxicity in CHO cells

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Clinical Biochemistry
Biochemistry, medical
Inorganic Chemistry

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10.1007/BF02785356

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title = "Effect of zinc on cadmium influx and toxicity in cultured CHO cells",

abstract = "Addition of zinc lowers the toxicity level of cadmium in cultured CHO cells. Cell survival and protein synthesis were used to measure the cellular toxicity of cadmium.109Cd was used to measure cadmium uptake by the cells. The results suggest that these class IIB transition metals, zinc and cadmium, share a common transport mechanism. Thus, the antagonism appears to involve a reduction in the influx of cadmium due to the presence of zinc.",

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T1 - Effect of zinc on cadmium influx and toxicity in cultured CHO cells

AU - Huang, P. C.

AU - Smith, Betty

AU - Bohdan, Patricia

AU - Corrigan, Alice

PY - 1980/9/1

Y1 - 1980/9/1

N2 - Addition of zinc lowers the toxicity level of cadmium in cultured CHO cells. Cell survival and protein synthesis were used to measure the cellular toxicity of cadmium.109Cd was used to measure cadmium uptake by the cells. The results suggest that these class IIB transition metals, zinc and cadmium, share a common transport mechanism. Thus, the antagonism appears to involve a reduction in the influx of cadmium due to the presence of zinc.

AB - Addition of zinc lowers the toxicity level of cadmium in cultured CHO cells. Cell survival and protein synthesis were used to measure the cellular toxicity of cadmium.109Cd was used to measure cadmium uptake by the cells. The results suggest that these class IIB transition metals, zinc and cadmium, share a common transport mechanism. Thus, the antagonism appears to involve a reduction in the influx of cadmium due to the presence of zinc.

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KW - Cadmium, influx and zinc in CHO cells

KW - antagonism, between zinc and cadmium in CHO cells

KW - metallothionein, and zinc/cadmium toxicity in CHO cells

KW - toxicity and zinc in CHO cells

KW - transport, of zinc and cadmium in CHO cells

KW - zinc, and cadmium influx and toxicity in CHO cells

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Effect of zinc on cadmium influx and toxicity in cultured CHO cells

Abstract

Keywords

ASJC Scopus subject areas

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