Effect of zinc and vitamin A supplementation on antibody responses to a pneumococcal conjugate vaccine in HIV-positive injection drug users: A randomized trial

Maria Deloria-Knoll; Mark Steinhoff; Richard D. Semba; Kenrad Nelson; David Vlahov; Curtis L. Meinert

doi:10.1016/j.vaccine.2005.09.047

Effect of zinc and vitamin A supplementation on antibody responses to a pneumococcal conjugate vaccine in HIV-positive injection drug users: A randomized trial

Maria Deloria-Knoll, Mark Steinhoff, Richard D. Semba, Kenrad Nelson, David Vlahov, Curtis L. Meinert

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

HIV-infected individuals have impaired immune responses to vaccines and high rates of pneumococcal disease. The effect of vitamin A and zinc supplementation on the immunogenicity of a 7-valent pneumococcal CRM-197 conjugate vaccine (PC-7) was evaluated in 118 HIV+ injection drug users. Subjects were randomized to oral 400,000 IU vitamin A, 300 mg zinc, vitamin A + zinc, or placebo, then immunized. Geometric mean titer increased 1.3-3.3-fold for all pneumococcal serotypes. PC-7 elicited an immune response in HIV-infected adults but neither vitamin A nor zinc altered the immunogenicity of the evaluated vaccines.

Original language	English (US)
Pages (from-to)	1670-1679
Number of pages	10
Journal	Vaccine
Volume	24
Issue number	10
DOIs	https://doi.org/10.1016/j.vaccine.2005.09.047
State	Published - Mar 6 2006

Keywords

HIV
Pneumococcal vaccine
Vitamin A
Zinc

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/j.vaccine.2005.09.047

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title = "Effect of zinc and vitamin A supplementation on antibody responses to a pneumococcal conjugate vaccine in HIV-positive injection drug users: A randomized trial",

abstract = "HIV-infected individuals have impaired immune responses to vaccines and high rates of pneumococcal disease. The effect of vitamin A and zinc supplementation on the immunogenicity of a 7-valent pneumococcal CRM-197 conjugate vaccine (PC-7) was evaluated in 118 HIV+ injection drug users. Subjects were randomized to oral 400,000 IU vitamin A, 300 mg zinc, vitamin A + zinc, or placebo, then immunized. Geometric mean titer increased 1.3-3.3-fold for all pneumococcal serotypes. PC-7 elicited an immune response in HIV-infected adults but neither vitamin A nor zinc altered the immunogenicity of the evaluated vaccines.",

keywords = "HIV, Pneumococcal vaccine, Vitamin A, Zinc",

author = "Maria Deloria-Knoll and Mark Steinhoff and Semba, {Richard D.} and Kenrad Nelson and David Vlahov and Meinert, {Curtis L.}",

note = "Funding Information: Supported by grants from Wyeth Vaccines, West Henrietta, NY 14586 and the National Institute on Drug Abuse (DA 04334). Thank you to Task Force Sight and Life, Hoffmann-LaRoche, Basel, Switzerland for providing the vitamin A capsules and to C. E. Jaimeson & Company Ltd., Winsor, Ontario, Canada for providing the zinc tablets used in this trial. ",

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T1 - Effect of zinc and vitamin A supplementation on antibody responses to a pneumococcal conjugate vaccine in HIV-positive injection drug users

T2 - A randomized trial

AU - Deloria-Knoll, Maria

AU - Steinhoff, Mark

AU - Semba, Richard D.

AU - Nelson, Kenrad

AU - Vlahov, David

AU - Meinert, Curtis L.

N1 - Funding Information: Supported by grants from Wyeth Vaccines, West Henrietta, NY 14586 and the National Institute on Drug Abuse (DA 04334). Thank you to Task Force Sight and Life, Hoffmann-LaRoche, Basel, Switzerland for providing the vitamin A capsules and to C. E. Jaimeson & Company Ltd., Winsor, Ontario, Canada for providing the zinc tablets used in this trial.

PY - 2006/3/6

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N2 - HIV-infected individuals have impaired immune responses to vaccines and high rates of pneumococcal disease. The effect of vitamin A and zinc supplementation on the immunogenicity of a 7-valent pneumococcal CRM-197 conjugate vaccine (PC-7) was evaluated in 118 HIV+ injection drug users. Subjects were randomized to oral 400,000 IU vitamin A, 300 mg zinc, vitamin A + zinc, or placebo, then immunized. Geometric mean titer increased 1.3-3.3-fold for all pneumococcal serotypes. PC-7 elicited an immune response in HIV-infected adults but neither vitamin A nor zinc altered the immunogenicity of the evaluated vaccines.

AB - HIV-infected individuals have impaired immune responses to vaccines and high rates of pneumococcal disease. The effect of vitamin A and zinc supplementation on the immunogenicity of a 7-valent pneumococcal CRM-197 conjugate vaccine (PC-7) was evaluated in 118 HIV+ injection drug users. Subjects were randomized to oral 400,000 IU vitamin A, 300 mg zinc, vitamin A + zinc, or placebo, then immunized. Geometric mean titer increased 1.3-3.3-fold for all pneumococcal serotypes. PC-7 elicited an immune response in HIV-infected adults but neither vitamin A nor zinc altered the immunogenicity of the evaluated vaccines.

KW - HIV

KW - Pneumococcal vaccine

KW - Vitamin A

KW - Zinc

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Effect of zinc and vitamin A supplementation on antibody responses to a pneumococcal conjugate vaccine in HIV-positive injection drug users: A randomized trial

Abstract

Keywords

ASJC Scopus subject areas

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