Abstract
Vitamin D status is conventionally defined by the serum concentration of 25-hydroxyvitamin D. However, it has been proposed that the serum cholecalciferol concentration (D3) also determines functional vitamin D sufficiency. The objective of this study was to describe the effect of weekly high-dose vitamin D3 supplementation on inter-dose serum D3 in pregnant women. We conducted a sub-study of a completed randomized double-blind placebo-controlled trial of vitamin D3 (35,000 IU/week) supplementation in late pregnancy (AViDD trial) in Dhaka, Bangladesh. This study included pregnant women enrolled at 26-29 weeks gestation who fully adhered to the prenatal supplement intervention for ≥8 consecutive weeks and for whom serum samples were available for D3 analysis (n = 65). Serum D3 was uniformly low at enrolment. Mean D3 increased and was maximal at 1 day after vitamin D dose administration (152.09 nmol/L, SD 25.11 nmol/L) and remained significantly higher in VitD vs. Pl at 7 days (29.59 nmol/L vs. 1.92 nmol/L, p = 0.007). Daily average of the group mean D3 during the week following dosing was 66.97 nmol/L in VitD versus 2.13 nmol/L in Pl. In conclusion, serum D3 remained significantly elevated throughout the week following ≥8 consecutive weekly doses of 35,000 IU D3 in pregnant women. However, the clinically significant minimum threshold of serum D3 remains to be established.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 76-81 |
| Number of pages | 6 |
| Journal | Journal of Steroid Biochemistry and Molecular Biology |
| Volume | 158 |
| DOIs | |
| State | Published - Apr 1 2016 |
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Keywords
- Bangladesh
- Cholecalciferol
- Pharmacokinetics
- Pregnancy
- Vitamin D
ASJC Scopus subject areas
- Biochemistry
- Clinical Biochemistry
- Endocrinology
- Cell Biology
- Molecular Biology
- Endocrinology, Diabetes and Metabolism
- Molecular Medicine
Cite this
Effect of weekly high-dose vitamin D3 supplementation on serum cholecalciferol concentrations in pregnant women. / Dimitris, Michelle C.; Perumal, Nandita; Craig-Barnes, Hayley A.; Leadley, Michael; Mahmud, Abdullah A.; Baqui, Abdullah; Roth, Daniel E.
In: Journal of Steroid Biochemistry and Molecular Biology, Vol. 158, 01.04.2016, p. 76-81.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of weekly high-dose vitamin D3 supplementation on serum cholecalciferol concentrations in pregnant women
AU - Dimitris, Michelle C.
AU - Perumal, Nandita
AU - Craig-Barnes, Hayley A.
AU - Leadley, Michael
AU - Mahmud, Abdullah A.
AU - Baqui, Abdullah
AU - Roth, Daniel E.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Vitamin D status is conventionally defined by the serum concentration of 25-hydroxyvitamin D. However, it has been proposed that the serum cholecalciferol concentration (D3) also determines functional vitamin D sufficiency. The objective of this study was to describe the effect of weekly high-dose vitamin D3 supplementation on inter-dose serum D3 in pregnant women. We conducted a sub-study of a completed randomized double-blind placebo-controlled trial of vitamin D3 (35,000 IU/week) supplementation in late pregnancy (AViDD trial) in Dhaka, Bangladesh. This study included pregnant women enrolled at 26-29 weeks gestation who fully adhered to the prenatal supplement intervention for ≥8 consecutive weeks and for whom serum samples were available for D3 analysis (n = 65). Serum D3 was uniformly low at enrolment. Mean D3 increased and was maximal at 1 day after vitamin D dose administration (152.09 nmol/L, SD 25.11 nmol/L) and remained significantly higher in VitD vs. Pl at 7 days (29.59 nmol/L vs. 1.92 nmol/L, p = 0.007). Daily average of the group mean D3 during the week following dosing was 66.97 nmol/L in VitD versus 2.13 nmol/L in Pl. In conclusion, serum D3 remained significantly elevated throughout the week following ≥8 consecutive weekly doses of 35,000 IU D3 in pregnant women. However, the clinically significant minimum threshold of serum D3 remains to be established.
AB - Vitamin D status is conventionally defined by the serum concentration of 25-hydroxyvitamin D. However, it has been proposed that the serum cholecalciferol concentration (D3) also determines functional vitamin D sufficiency. The objective of this study was to describe the effect of weekly high-dose vitamin D3 supplementation on inter-dose serum D3 in pregnant women. We conducted a sub-study of a completed randomized double-blind placebo-controlled trial of vitamin D3 (35,000 IU/week) supplementation in late pregnancy (AViDD trial) in Dhaka, Bangladesh. This study included pregnant women enrolled at 26-29 weeks gestation who fully adhered to the prenatal supplement intervention for ≥8 consecutive weeks and for whom serum samples were available for D3 analysis (n = 65). Serum D3 was uniformly low at enrolment. Mean D3 increased and was maximal at 1 day after vitamin D dose administration (152.09 nmol/L, SD 25.11 nmol/L) and remained significantly higher in VitD vs. Pl at 7 days (29.59 nmol/L vs. 1.92 nmol/L, p = 0.007). Daily average of the group mean D3 during the week following dosing was 66.97 nmol/L in VitD versus 2.13 nmol/L in Pl. In conclusion, serum D3 remained significantly elevated throughout the week following ≥8 consecutive weekly doses of 35,000 IU D3 in pregnant women. However, the clinically significant minimum threshold of serum D3 remains to be established.
KW - Bangladesh
KW - Cholecalciferol
KW - Pharmacokinetics
KW - Pregnancy
KW - Vitamin D
UR - http://www.scopus.com/inward/record.url?scp=84960418725&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84960418725&partnerID=8YFLogxK
U2 - 10.1016/j.jsbmb.2016.01.007
DO - 10.1016/j.jsbmb.2016.01.007
M3 - Article
C2 - 26784272
AN - SCOPUS:84960418725
VL - 158
SP - 76
EP - 81
JO - Journal of Steroid Biochemistry and Molecular Biology
JF - Journal of Steroid Biochemistry and Molecular Biology
SN - 0960-0760
ER -