Abstract
Vitamin D status is conventionally defined by the serum concentration of 25-hydroxyvitamin D. However, it has been proposed that the serum cholecalciferol concentration (D3) also determines functional vitamin D sufficiency. The objective of this study was to describe the effect of weekly high-dose vitamin D3 supplementation on inter-dose serum D3 in pregnant women. We conducted a sub-study of a completed randomized double-blind placebo-controlled trial of vitamin D3 (35,000 IU/week) supplementation in late pregnancy (AViDD trial) in Dhaka, Bangladesh. This study included pregnant women enrolled at 26-29 weeks gestation who fully adhered to the prenatal supplement intervention for ≥8 consecutive weeks and for whom serum samples were available for D3 analysis (n = 65). Serum D3 was uniformly low at enrolment. Mean D3 increased and was maximal at 1 day after vitamin D dose administration (152.09 nmol/L, SD 25.11 nmol/L) and remained significantly higher in VitD vs. Pl at 7 days (29.59 nmol/L vs. 1.92 nmol/L, p = 0.007). Daily average of the group mean D3 during the week following dosing was 66.97 nmol/L in VitD versus 2.13 nmol/L in Pl. In conclusion, serum D3 remained significantly elevated throughout the week following ≥8 consecutive weekly doses of 35,000 IU D3 in pregnant women. However, the clinically significant minimum threshold of serum D3 remains to be established.
Original language | English (US) |
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Pages (from-to) | 76-81 |
Number of pages | 6 |
Journal | Journal of Steroid Biochemistry and Molecular Biology |
Volume | 158 |
DOIs | |
State | Published - Apr 1 2016 |
Keywords
- Bangladesh
- Cholecalciferol
- Pharmacokinetics
- Pregnancy
- Vitamin D
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Endocrinology
- Clinical Biochemistry
- Cell Biology