Effect of weekly high-dose vitamin D3 supplementation on serum cholecalciferol concentrations in pregnant women

Michelle C. Dimitris, Nandita Perumal, Hayley A. Craig-Barnes, Michael Leadley, Abdullah A. Mahmud, Abdullah H. Baqui, Daniel E. Roth

Research output: Contribution to journalArticlepeer-review

Abstract

Vitamin D status is conventionally defined by the serum concentration of 25-hydroxyvitamin D. However, it has been proposed that the serum cholecalciferol concentration (D3) also determines functional vitamin D sufficiency. The objective of this study was to describe the effect of weekly high-dose vitamin D3 supplementation on inter-dose serum D3 in pregnant women. We conducted a sub-study of a completed randomized double-blind placebo-controlled trial of vitamin D3 (35,000 IU/week) supplementation in late pregnancy (AViDD trial) in Dhaka, Bangladesh. This study included pregnant women enrolled at 26-29 weeks gestation who fully adhered to the prenatal supplement intervention for ≥8 consecutive weeks and for whom serum samples were available for D3 analysis (n = 65). Serum D3 was uniformly low at enrolment. Mean D3 increased and was maximal at 1 day after vitamin D dose administration (152.09 nmol/L, SD 25.11 nmol/L) and remained significantly higher in VitD vs. Pl at 7 days (29.59 nmol/L vs. 1.92 nmol/L, p = 0.007). Daily average of the group mean D3 during the week following dosing was 66.97 nmol/L in VitD versus 2.13 nmol/L in Pl. In conclusion, serum D3 remained significantly elevated throughout the week following ≥8 consecutive weekly doses of 35,000 IU D3 in pregnant women. However, the clinically significant minimum threshold of serum D3 remains to be established.

Original languageEnglish (US)
Pages (from-to)76-81
Number of pages6
JournalJournal of Steroid Biochemistry and Molecular Biology
Volume158
DOIs
StatePublished - Apr 1 2016

Keywords

  • Bangladesh
  • Cholecalciferol
  • Pharmacokinetics
  • Pregnancy
  • Vitamin D

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Endocrinology
  • Clinical Biochemistry
  • Cell Biology

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