Effect of Vitamin A supplementation on the immune response to measles vaccination

Thomas Cherian; Sneha Varkki; P. Raghupathy; Sam Ratnam; Ranjit K. Chandra

doi:10.1016/S0264-410X(03)00060-4

Effect of Vitamin A supplementation on the immune response to measles vaccination

Thomas Cherian, Sneha Varkki, P. Raghupathy, Sam Ratnam, Ranjit K. Chandra

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

A randomized controlled trial was conducted in 395 infants aged 9-12 months to determine the effect of Vitamin A supplementation on concurrently administered measles vaccine. Antibody response was measured using the plaque reduction neutralization assay. No statistically significant differences were demonstrated between the immune response in Vitamin A supplemented and unsupplemented children. Unlike some recent studies, we were unable to demonstrate an immune enhancing effect of Vitamin A supplementation. On the contrary, among children who were given Vitamin A, a lower, but statistically non-significant, proportion had protective antibody levels 6 months after vaccination.

Original language	English (US)
Pages (from-to)	2418-2420
Number of pages	3
Journal	Vaccine
Volume	21
Issue number	19-20
DOIs	https://doi.org/10.1016/S0264-410X(03)00060-4
State	Published - Jun 2 2003
Externally published	Yes

Keywords

Immune response
Measles vaccine
Vitamin A

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/S0264-410X(03)00060-4

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abstract = "A randomized controlled trial was conducted in 395 infants aged 9-12 months to determine the effect of Vitamin A supplementation on concurrently administered measles vaccine. Antibody response was measured using the plaque reduction neutralization assay. No statistically significant differences were demonstrated between the immune response in Vitamin A supplemented and unsupplemented children. Unlike some recent studies, we were unable to demonstrate an immune enhancing effect of Vitamin A supplementation. On the contrary, among children who were given Vitamin A, a lower, but statistically non-significant, proportion had protective antibody levels 6 months after vaccination.",

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AU - Raghupathy, P.

AU - Ratnam, Sam

AU - Chandra, Ranjit K.

PY - 2003/6/2

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AB - A randomized controlled trial was conducted in 395 infants aged 9-12 months to determine the effect of Vitamin A supplementation on concurrently administered measles vaccine. Antibody response was measured using the plaque reduction neutralization assay. No statistically significant differences were demonstrated between the immune response in Vitamin A supplemented and unsupplemented children. Unlike some recent studies, we were unable to demonstrate an immune enhancing effect of Vitamin A supplementation. On the contrary, among children who were given Vitamin A, a lower, but statistically non-significant, proportion had protective antibody levels 6 months after vaccination.

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KW - Measles vaccine

KW - Vitamin A

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Effect of Vitamin A supplementation on the immune response to measles vaccination

Abstract

Keywords

ASJC Scopus subject areas

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