Effect of Vitamin A supplementation on the immune response to measles vaccination

Thomas Cherian, Sneha Varkki, P. Raghupathy, Sam Ratnam, Ranjit K. Chandra

Research output: Contribution to journalArticle

Abstract

A randomized controlled trial was conducted in 395 infants aged 9-12 months to determine the effect of Vitamin A supplementation on concurrently administered measles vaccine. Antibody response was measured using the plaque reduction neutralization assay. No statistically significant differences were demonstrated between the immune response in Vitamin A supplemented and unsupplemented children. Unlike some recent studies, we were unable to demonstrate an immune enhancing effect of Vitamin A supplementation. On the contrary, among children who were given Vitamin A, a lower, but statistically non-significant, proportion had protective antibody levels 6 months after vaccination.

Original languageEnglish (US)
Pages (from-to)2418-2420
Number of pages3
JournalVaccine
Volume21
Issue number19-20
DOIs
StatePublished - Jun 2 2003
Externally publishedYes

Fingerprint

Measles
Vitamin A
vitamin A
Vaccination
vaccination
immune response
Measles Vaccine
antibodies
neutralization tests
Antibody Formation
Randomized Controlled Trials
vaccines
Antibodies

Keywords

  • Immune response
  • Measles vaccine
  • Vitamin A

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Effect of Vitamin A supplementation on the immune response to measles vaccination. / Cherian, Thomas; Varkki, Sneha; Raghupathy, P.; Ratnam, Sam; Chandra, Ranjit K.

In: Vaccine, Vol. 21, No. 19-20, 02.06.2003, p. 2418-2420.

Research output: Contribution to journalArticle

Cherian, T, Varkki, S, Raghupathy, P, Ratnam, S & Chandra, RK 2003, 'Effect of Vitamin A supplementation on the immune response to measles vaccination', Vaccine, vol. 21, no. 19-20, pp. 2418-2420. https://doi.org/10.1016/S0264-410X(03)00060-4
Cherian, Thomas ; Varkki, Sneha ; Raghupathy, P. ; Ratnam, Sam ; Chandra, Ranjit K. / Effect of Vitamin A supplementation on the immune response to measles vaccination. In: Vaccine. 2003 ; Vol. 21, No. 19-20. pp. 2418-2420.
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