TY - JOUR
T1 - Effect of vitamin A supplementation on measles vaccination in nine-month-old infants
AU - Semba, R. D.
AU - Akib, A.
AU - Beeler, J.
AU - Munasir, Z.
AU - Permaesih, D.
AU - Muherdiyantiningsih,
AU - Komala,
AU - Martuti, S.
AU - Muhilal,
N1 - Funding Information:
This study was supported by grants from the National Institutes of Health (AI35143, HD30042), the Thrasher Research Fund, the WHO Expanded Programme on Immunization, and the Office of Nutrition, Bureau for Science and Technology, US Agency for International Development (Cooperative Agreement DAN-0045-A-5094-00). The authors wish to acknowledge the staff of the Nutrition Research and Development Center for the field support, Biocine Sclavo, Siena, Italy, for donation of measles vaccine, and Task Force Sight and Life, Basel, Switzerland, for donation of vitamin A and placebo capsules. Technical support was provided by Susette Audet.
PY - 1997
Y1 - 1997
N2 - Objective: Childhood immunization programs have been suggested as an infrastructure to deliver vitamin A supplements to children in developing countries. The effects of giving vitamin A, a potent immune enhancer, with measles immunization to nine-month-old infants is unknown. Methods: A randomized, double-masked, placebo-controlled clinical trial of vitamin A, 100,000 IU at the time of standard titer Schwarz measles immunization was conducted with nine-month-old infants in Bogor District, West Java, Indonesia. Antibody titers to measles were measured at baseline and one and six months following immunization. Results: 394 infants received measles immunization, and 37 infants (9.4%) had baseline antibody titers > 1:120, which is consistent with previous natural measles infection. Of the remaining infants, 98.8% seroconverted to measles, and 99.3% had titers consistent with protection against measles six months postimmunization. Seroconversion rates were similar in vitamin A and placebo treatment groups. Conclusion: High dose vitamin A supplementation can be given without reducing seroconversion to standard titer Schwarz measles immunization in nine-month-old infants.
AB - Objective: Childhood immunization programs have been suggested as an infrastructure to deliver vitamin A supplements to children in developing countries. The effects of giving vitamin A, a potent immune enhancer, with measles immunization to nine-month-old infants is unknown. Methods: A randomized, double-masked, placebo-controlled clinical trial of vitamin A, 100,000 IU at the time of standard titer Schwarz measles immunization was conducted with nine-month-old infants in Bogor District, West Java, Indonesia. Antibody titers to measles were measured at baseline and one and six months following immunization. Results: 394 infants received measles immunization, and 37 infants (9.4%) had baseline antibody titers > 1:120, which is consistent with previous natural measles infection. Of the remaining infants, 98.8% seroconverted to measles, and 99.3% had titers consistent with protection against measles six months postimmunization. Seroconversion rates were similar in vitamin A and placebo treatment groups. Conclusion: High dose vitamin A supplementation can be given without reducing seroconversion to standard titer Schwarz measles immunization in nine-month-old infants.
KW - Indonesia
KW - Measles
KW - Retinol
KW - Vaccination
KW - Vitamin A
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U2 - 10.1016/S0033-3506(97)00042-5
DO - 10.1016/S0033-3506(97)00042-5
M3 - Article
C2 - 9242038
AN - SCOPUS:0030762712
SN - 0033-3506
VL - 111
SP - 245
EP - 247
JO - Public Health
JF - Public Health
IS - 4
ER -