Effect of vitamin A on the mucopolysaccharides of lung tissue

L. De Luca, G. Wolf

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Three distinct mucopolysaccharide-peptide complexes have been isolated from lung tissue and identified by the following procedures as hyaluronic acid, a sulfated hyaluronic acid, and heparan sulfate: elution pattern from DEAE-Sephadex columns and paper electrophoresis; analysis of chemical composition; and susceptibility or resistance to hyaluronidase or heparinase digestion. The incorporation of 35SO2-4 and glucosamine-1-14C into these mucopolysaccharides and into cartilage chondroitin sulfate of vitamin A-normal and vitamin A-deficient pair-fed rats was studied. The amount of each compound was higher in the vitamin A-deficient animals. The distribution of label in the unsulfated and less sulfated mucopolysaccharides showed higher values in the vitamin A-deficient animals. The lung heparan sulfate and inter-costal cartilage chondroitin sulfate, on the other hand, had a higher incorporation of labeled sulfate in vitamin A-normal compared with vitamin A-deficient animals.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalArchives of Biochemistry and Biophysics
Volume123
Issue number1
DOIs
StatePublished - Jan 1968
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology

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