Effect of Various Surface Active Agents on Heparin Binding and Clot Formation on Graphite Surfaces

James D. Whiffen, Vincent L. Gott

Research output: Contribution to journalArticlepeer-review

Abstract

Various surface-active agents were evaluated for their ability to bind heparin to graphite-coated plastic and thus produce a prosthetic surface resistant to thrombus formation. Both in vitro and in vivo studies indicated that only cationic agents bound heparin to graphite. After the positively charged cationic agent is adsorbed to the graphite surface, it can in turn bind the negatively charged heparin and thus present to the blood stream, at least initially, a surface rich in heparin.

Original languageEnglish (US)
Pages (from-to)314-317
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume116
Issue number2
DOIs
StatePublished - Jun 1964
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint

Dive into the research topics of 'Effect of Various Surface Active Agents on Heparin Binding and Clot Formation on Graphite Surfaces'. Together they form a unique fingerprint.

Cite this