Effect of urbanisation on the relationship between total serum IgE and asthma

William Checkley, Colin L. Robinson, Lauren M. Baumann, Karina Romero, Juan M. Combe, Robert H Gilman, Robert A Wise, Robert G Hamilton, Guillermo Gonzalvez, Vitaliano Cama, Nadia Hansel

Research output: Contribution to journalArticle

Abstract

It is unclear if the relationship of total serum IgE with asthma varies with degree of urbanisation. We hypothesised that the relationship of total serum IgE to asthma is more pronounced in an urban versus a rural environment. We enrolled 1441 children aged 13-15 years in a peri-urban shanty town in Lima, Peru (n=725) and 23 villages in rural Tumbes, Peru (n=716). We asked participants about asthma and allergy symptoms, environmental exposures and sociodemographics; and performed spirometry, and exhaled nitric oxide and allergy skin testing. We obtained blood for total serum IgE in 1143 (79%) participants. Geometric means for total serum IgE were higher in Lima versus Tumbes (262 versus 192 kU·L-1; p

Original languageEnglish (US)
Pages (from-to)1074-1081
Number of pages8
JournalEuropean Respiratory Journal
Volume41
Issue number5
DOIs
StatePublished - May 1 2013

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Urbanization
Immunoglobulin E
Asthma
Peru
Serum
Hypersensitivity
Spirometry
Environmental Exposure
Nitric Oxide
Skin

Keywords

  • Asthma clinical/basic investigations
  • Atopic asthma
  • Epidemiology of asthma

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Effect of urbanisation on the relationship between total serum IgE and asthma. / Checkley, William; Robinson, Colin L.; Baumann, Lauren M.; Romero, Karina; Combe, Juan M.; Gilman, Robert H; Wise, Robert A; Hamilton, Robert G; Gonzalvez, Guillermo; Cama, Vitaliano; Hansel, Nadia.

In: European Respiratory Journal, Vol. 41, No. 5, 01.05.2013, p. 1074-1081.

Research output: Contribution to journalArticle

Checkley, William ; Robinson, Colin L. ; Baumann, Lauren M. ; Romero, Karina ; Combe, Juan M. ; Gilman, Robert H ; Wise, Robert A ; Hamilton, Robert G ; Gonzalvez, Guillermo ; Cama, Vitaliano ; Hansel, Nadia. / Effect of urbanisation on the relationship between total serum IgE and asthma. In: European Respiratory Journal. 2013 ; Vol. 41, No. 5. pp. 1074-1081.
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