Effect of Ultraviolet Radiation on Cataract Formation

Hugh R. Taylor, Sheila K. West, Frank S. Rosenthal, Beatriz Muñoz, Henry S. Newland, Helen Abbey, Edward A. Emmett

Research output: Contribution to journalArticle

Abstract

To investigate the relation of ultraviolet radiation and cataract formation, we undertook an epidemiologc survey of 838 watermen (mean age, 53 years) who worked on Chesapeake Bay. The annual ocular exposure was calculated from the age of 16 for each waterman by combining a detailed occupational history with laboratory and field measurements of sun exposure. Cataracts were graded by ophthalmologic examination for both type and severity. Some degree of cortical cataract was found in 111 of the watermen (13 percent), and some degree of nuclear cataract in 229 (27 percent). Logistic regression analysis showed that high cumulative levels of ultraviolet B exposure significantly increased the risk of cortical cataract (regression coefficient, 0.70; P = 0.04). A doubling of cumulative exposure increased the risk of cortical cataract by a factor of 1.60 (95 percent confidence interval, 1.01 to 2.64). Those whose annual average exposure was in the upper quartile had a risk increased by 3.30 (confidence interval, 0.90 to 9.97) as compared with those in the lowest quartile. Analysis using a serially additive expected-dose model showed that watermen with cortical lens opacities had a 21 percent higher average annual exposure to ultraviolet B (t-test, 2.23; P = 0.03). No association was found between nuclear cataracts and ultraviolet B exposure or between cataracts and ultraviolet A exposure. We conclude that there is an association between exposure to ultraviolet B radiation and cataract formation, which supports the need for ocular protection from ultraviolet B. (N Engl J Med 1988; 319:1429–33.)

Original languageEnglish (US)
Pages (from-to)1429-1433
Number of pages5
JournalNew England Journal of Medicine
Volume319
Issue number22
DOIs
StatePublished - Dec 1 1988

ASJC Scopus subject areas

  • Medicine(all)

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    Taylor, H. R., West, S. K., Rosenthal, F. S., Muñoz, B., Newland, H. S., Abbey, H., & Emmett, E. A. (1988). Effect of Ultraviolet Radiation on Cataract Formation. New England Journal of Medicine, 319(22), 1429-1433. https://doi.org/10.1056/NEJM198812013192201