Effect of treatment of anaemia with erythropoietin on neuromuscular function in patients on long term haemodialysis

Mohamed A. Sobh, Abd El Halim El-Tantawy, Ehab Said, Mohamed Gehad Atta, Ayman Refaie, Mohamed Nagati, Mohamed Ghoneim

Research output: Contribution to journalArticlepeer-review

Abstract

To study the effect of treatment of anaemia with recombinant human erythropoietin (r-HUEPO) on neuromuscular function in patients undergoing haemodialysis for chronic renal failure, six patients were given r-HUEPO in an initial dose of 50 u/kg three times a week and their haemoglobin concentration was measured. The dose was increased by 25 u/kg every four weeks if the response was not satisfactory. In five patients anaemia had been corrected within 12 weeks of initiation of treatment. Neuromuscular function was evaluated before treatment, half way through, and after correction of anaemia by clinical examination and neurophysiological studies including motor nerve conduction velocity, distal latency, electromyography and test for neuromuscular fatigue. After correction of anaemia there was a significant increase in motor nerve conduction velocity, a decrease in the duration of motor unit action potential, and a lessening of neuromuscular fatigue. We conclude that treatment of anaemia with r-HUEPO in patients with chronic renal failure undergoing haemodialysis may improve neuromuscular function.

Original languageEnglish (US)
Pages (from-to)65-69
Number of pages5
JournalScandinavian Journal of Urology and Nephrology
Volume26
Issue number1
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

Keywords

  • Anaemia
  • Dialysis
  • Erythropoietin
  • Neuromuscular

ASJC Scopus subject areas

  • Nephrology
  • Urology

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