Effect of the peroxisome proliferatorsactivated receptor (PPAR) gamma 3 gene on BMI in 1,210 school students from morelos, Mexico

Una Chen, H. Eduardo Velasco Mondragon, Eduardo Lazcanoponce, Andrew Collins, Yin Yao Shugart

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Little research has been undertaken on risk factors for obesity in young people in Latin America, including Mexico, despite the fact that obesity constitutes the number one public health problem in Mexico. Our objective was to investigate the effect of the Peroxisome proliferators-activated receptor (PPAR)-3 gene on BMI measured among adolescents collected from a cohort study originally designed for epidemiological studies. METHODS: Blood samples and anthropometric measurements were collected from 1,210 out of 13,294 public school students of both sexes, aged 11-24 years in Morelos, Mexico. In this study, we genotyped 7 selected SNPs of the PPAR- transcript variant 3 (including Prol2Ala) in a group of unrelated 717 males and 493 females (age range 11-24), including 3 SNPs located in the 5' untranslated region. These 7 SNPs were selected by the tagging algorithm implemented in the program haploview to scan the whole gene. We tested each of the 7 SNPs individually for association with the body mass index (BMI), and two SNPs (rs2938392 and is 1175542) revealed significant associations with BMI (p-value=0.008 and 0.029, respectively). The SNP rs2938392 is roughly 41.5 Kb from rs1801282 (Prol2Ala in PPAR-2). Furthermore, we examined the association between haplotypes built from 7 SNPs and BMI using a score statistic implemented in the program haplo.stats. While the permutation based global p-value was 0.S44, one individual haplotype with a frequency of 0.279 gave a p-value of 0.089 (permutation based). However, when the analyses were conducted in males only, the permutation based global p-valuc was 0.055 and one individual haplotype with a frequency of 0.28 gave a significant p-value of 0.013.

Original languageEnglish (US)
Title of host publicationProceedings of the Pacific Symposium on Biocomputing 2006, PSB 2006
Pages467-477
Number of pages11
StatePublished - 2006
Event11th Pacific Symposium on Biocomputing 2006, PSB 2006 - Maui, HI, United States
Duration: Jan 3 2006Jan 7 2006

Other

Other11th Pacific Symposium on Biocomputing 2006, PSB 2006
CountryUnited States
CityMaui, HI
Period1/3/061/7/06

ASJC Scopus subject areas

  • Computational Theory and Mathematics
  • Biomedical Engineering
  • Medicine(all)

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