Effect of the mitral valve on diastolic flow patterns

Jung Hee Seo, Vijay Vedula, Theodore Abraham, Albert C. Lardo, Fady Dawoud, Hongchang Luo, Rajat Mittal

Research output: Contribution to journalArticle

Abstract

The leaflets of the mitral valve interact with the mitral jet and significantly impact diastolic flow patterns, but the effect of mitral valve morphology and kinematics on diastolic flow and its implications for left ventricular function have not been clearly delineated. In the present study, we employ computational hemodynamic simulations to understand the effect of mitral valve leaflets on diastolic flow. A computational model of the left ventricle is constructed based on a high-resolution contrast computed-tomography scan, and a physiological inspired model of the mitral valve leaflets is synthesized from morphological and echocardiographic data. Simulations are performed with a diode type valve model as well as the physiological mitral valve model in order to delineate the effect of mitral-valve leaflets on the intraventricular flow. The study suggests that a normal physiological mitral valve promotes the formation of a circulatory (or "looped") flow pattern in the ventricle. The mitral valve leaflets also increase the strength of the apical flow, thereby enhancing apical washout and mixing of ventricular blood. The implications of these findings on ventricular function as well as ventricular flow models are discussed.

Original languageEnglish (US)
Article number1.4904094
JournalPhysics of Fluids
Volume26
Issue number12
DOIs
StatePublished - Dec 18 2014

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Flow patterns
flow distribution
Physiological models
Hemodynamics
Tomography
Kinematics
Diodes
Blood
hemodynamics
fallout
blood
kinematics
simulation
tomography
diodes
high resolution

ASJC Scopus subject areas

  • Condensed Matter Physics

Cite this

Seo, J. H., Vedula, V., Abraham, T., Lardo, A. C., Dawoud, F., Luo, H., & Mittal, R. (2014). Effect of the mitral valve on diastolic flow patterns. Physics of Fluids, 26(12), [1.4904094]. https://doi.org/10.1063/1.4904094

Effect of the mitral valve on diastolic flow patterns. / Seo, Jung Hee; Vedula, Vijay; Abraham, Theodore; Lardo, Albert C.; Dawoud, Fady; Luo, Hongchang; Mittal, Rajat.

In: Physics of Fluids, Vol. 26, No. 12, 1.4904094, 18.12.2014.

Research output: Contribution to journalArticle

Seo, JH, Vedula, V, Abraham, T, Lardo, AC, Dawoud, F, Luo, H & Mittal, R 2014, 'Effect of the mitral valve on diastolic flow patterns', Physics of Fluids, vol. 26, no. 12, 1.4904094. https://doi.org/10.1063/1.4904094
Seo JH, Vedula V, Abraham T, Lardo AC, Dawoud F, Luo H et al. Effect of the mitral valve on diastolic flow patterns. Physics of Fluids. 2014 Dec 18;26(12). 1.4904094. https://doi.org/10.1063/1.4904094
Seo, Jung Hee ; Vedula, Vijay ; Abraham, Theodore ; Lardo, Albert C. ; Dawoud, Fady ; Luo, Hongchang ; Mittal, Rajat. / Effect of the mitral valve on diastolic flow patterns. In: Physics of Fluids. 2014 ; Vol. 26, No. 12.
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