Abstract
The effect of the levonorgestrel-releasing intrauterine device (LNG-IUD) on genital HIV-1 RNA shedding and inflammation among 25 HIV-infected women was evaluated. Blood, endocervical, and cervicovaginal lavage samples were collected from HIV-infected women not taking antiretrovirals before LNG-IUD insertion and 1 month, 3 month, and 6 months thereafter. HIV-1 RNA was quantitated by real-time reverse transcriptase-polymerase chain reaction. Inflammatory markers were measured by enzyme immunoassay. Genital HIV-1 RNA shedding and inflammatory markers did not differ between LNG-IUD placement and month 6, with the exception of interleukin 1b that increased (0.42 log10; 95% confidence interval: 0.10 to 0.75). The LNG-IUD did not increase genital HIV-1 RNA shedding after 6 months of use.
Original language | English (US) |
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Pages (from-to) | 245-248 |
Number of pages | 4 |
Journal | Journal of Acquired Immune Deficiency Syndromes |
Volume | 63 |
Issue number | 2 |
DOIs | |
State | Published - Jun 1 2013 |
Keywords
- Genital HIV shedding
- HIV infection
- IUD
- Levonorgestrel
ASJC Scopus subject areas
- Infectious Diseases
- Pharmacology (medical)