Effect of the levonorgestrel intrauterine device on genital HIV-1 RNA shedding among HIV-1-infected women not taking antiretroviral therapy in Nairobi, Kenya

Jenell S. Coleman, Christina Mwachari, Jennifer Balkus, Lucy Sanguli, Angela Muliro, Kathy Agnew, Robert W. Coombs, Craig R. Cohen, Jane Hitti

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of the levonorgestrel-releasing intrauterine device (LNG-IUD) on genital HIV-1 RNA shedding and inflammation among 25 HIV-infected women was evaluated. Blood, endocervical, and cervicovaginal lavage samples were collected from HIV-infected women not taking antiretrovirals before LNG-IUD insertion and 1 month, 3 month, and 6 months thereafter. HIV-1 RNA was quantitated by real-time reverse transcriptase-polymerase chain reaction. Inflammatory markers were measured by enzyme immunoassay. Genital HIV-1 RNA shedding and inflammatory markers did not differ between LNG-IUD placement and month 6, with the exception of interleukin 1b that increased (0.42 log10; 95% confidence interval: 0.10 to 0.75). The LNG-IUD did not increase genital HIV-1 RNA shedding after 6 months of use.

Original languageEnglish (US)
Pages (from-to)245-248
Number of pages4
JournalJournal of acquired immune deficiency syndromes
Volume63
Issue number2
DOIs
StatePublished - Jun 1 2013

Keywords

  • Genital HIV shedding
  • HIV infection
  • IUD
  • Levonorgestrel

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Effect of the levonorgestrel intrauterine device on genital HIV-1 RNA shedding among HIV-1-infected women not taking antiretroviral therapy in Nairobi, Kenya'. Together they form a unique fingerprint.

Cite this