Effect of the levonorgestrel intrauterine device on genital HIV-1 RNA shedding among HIV-1-infected women not taking antiretroviral therapy in Nairobi, Kenya

Jenell S. Coleman Fennell, Christina Mwachari, Jennifer Balkus, Lucy Sanguli, Angela Muliro, Kathy Agnew, Robert W. Coombs, Craig R. Cohen, Jane Hitti

Research output: Contribution to journalArticle

Abstract

The effect of the levonorgestrel-releasing intrauterine device (LNG-IUD) on genital HIV-1 RNA shedding and inflammation among 25 HIV-infected women was evaluated. Blood, endocervical, and cervicovaginal lavage samples were collected from HIV-infected women not taking antiretrovirals before LNG-IUD insertion and 1 month, 3 month, and 6 months thereafter. HIV-1 RNA was quantitated by real-time reverse transcriptase-polymerase chain reaction. Inflammatory markers were measured by enzyme immunoassay. Genital HIV-1 RNA shedding and inflammatory markers did not differ between LNG-IUD placement and month 6, with the exception of interleukin 1b that increased (0.42 log10; 95% confidence interval: 0.10 to 0.75). The LNG-IUD did not increase genital HIV-1 RNA shedding after 6 months of use.

Original languageEnglish (US)
Pages (from-to)245-248
Number of pages4
JournalJournal of Acquired Immune Deficiency Syndromes
Volume63
Issue number2
DOIs
StatePublished - Jun 1 2013

Fingerprint

Levonorgestrel
Intrauterine Devices
Kenya
HIV-1
RNA
HIV
Interleukins
Therapeutic Irrigation
Therapeutics
Reverse Transcriptase Polymerase Chain Reaction
Immunoenzyme Techniques
Real-Time Polymerase Chain Reaction
Confidence Intervals
Inflammation

Keywords

  • Genital HIV shedding
  • HIV infection
  • IUD
  • Levonorgestrel

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)
  • Medicine(all)

Cite this

Effect of the levonorgestrel intrauterine device on genital HIV-1 RNA shedding among HIV-1-infected women not taking antiretroviral therapy in Nairobi, Kenya. / Coleman Fennell, Jenell S.; Mwachari, Christina; Balkus, Jennifer; Sanguli, Lucy; Muliro, Angela; Agnew, Kathy; Coombs, Robert W.; Cohen, Craig R.; Hitti, Jane.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 63, No. 2, 01.06.2013, p. 245-248.

Research output: Contribution to journalArticle

Coleman Fennell, Jenell S. ; Mwachari, Christina ; Balkus, Jennifer ; Sanguli, Lucy ; Muliro, Angela ; Agnew, Kathy ; Coombs, Robert W. ; Cohen, Craig R. ; Hitti, Jane. / Effect of the levonorgestrel intrauterine device on genital HIV-1 RNA shedding among HIV-1-infected women not taking antiretroviral therapy in Nairobi, Kenya. In: Journal of Acquired Immune Deficiency Syndromes. 2013 ; Vol. 63, No. 2. pp. 245-248.
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