Effect of the ionophore monensin on herpes simplex virus Type 1-induced cell fusion, glycoprotein synthesis, and virion infectivity

Konstantin G. Kousoulas; David J. Bzik; Stanley Person

doi:10.1159/000149375

Effect of the ionophore monensin on herpes simplex virus Type 1-induced cell fusion, glycoprotein synthesis, and virion infectivity

Konstantin G. Kousoulas, David J. Bzik, Stanley Person

School of Medicine

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The ionophore monensin inhibited the formation of mature, fully glycosylated glycoproteins gB, gC, and gD during herpes simplex virus type 1 infection of human embryonic lung cells. Underglycosylated forms, including the apparent high-mannose precursor forms of the major glycoproteins, appeared. Monensin inhibited virus-induced cell fusion. Infectious virions produced in the presence of monensin appeared to contain predominantly underglycosylated glycoproteins.

Original language	English (US)
Pages (from-to)	56-60
Number of pages	5
Journal	Intervirology
Volume	20
Issue number	1
DOIs	https://doi.org/10.1159/000149375
State	Published - 1983

Keywords

Cell fusion
Glycoprotein synthesis
Herpes simplex virus type 1
Infectious virus
Monensin

ASJC Scopus subject areas

Virology
Infectious Diseases

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10.1159/000149375

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abstract = "The ionophore monensin inhibited the formation of mature, fully glycosylated glycoproteins gB, gC, and gD during herpes simplex virus type 1 infection of human embryonic lung cells. Underglycosylated forms, including the apparent high-mannose precursor forms of the major glycoproteins, appeared. Monensin inhibited virus-induced cell fusion. Infectious virions produced in the presence of monensin appeared to contain predominantly underglycosylated glycoproteins.",

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author = "Kousoulas, {Konstantin G.} and Bzik, {David J.} and Stanley Person",

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AU - Kousoulas, Konstantin G.

AU - Bzik, David J.

AU - Person, Stanley

PY - 1983

Y1 - 1983

N2 - The ionophore monensin inhibited the formation of mature, fully glycosylated glycoproteins gB, gC, and gD during herpes simplex virus type 1 infection of human embryonic lung cells. Underglycosylated forms, including the apparent high-mannose precursor forms of the major glycoproteins, appeared. Monensin inhibited virus-induced cell fusion. Infectious virions produced in the presence of monensin appeared to contain predominantly underglycosylated glycoproteins.

AB - The ionophore monensin inhibited the formation of mature, fully glycosylated glycoproteins gB, gC, and gD during herpes simplex virus type 1 infection of human embryonic lung cells. Underglycosylated forms, including the apparent high-mannose precursor forms of the major glycoproteins, appeared. Monensin inhibited virus-induced cell fusion. Infectious virions produced in the presence of monensin appeared to contain predominantly underglycosylated glycoproteins.

KW - Cell fusion

KW - Glycoprotein synthesis

KW - Herpes simplex virus type 1

KW - Infectious virus

KW - Monensin

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Effect of the ionophore monensin on herpes simplex virus Type 1-induced cell fusion, glycoprotein synthesis, and virion infectivity

Abstract

Keywords

ASJC Scopus subject areas

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