Effect of the ionophore monensin on herpes simplex virus Type 1-induced cell fusion, glycoprotein synthesis, and virion infectivity

Konstantin G. Kousoulas, David J. Bzik, Stanley Person

Research output: Contribution to journalArticlepeer-review

Abstract

The ionophore monensin inhibited the formation of mature, fully glycosylated glycoproteins gB, gC, and gD during herpes simplex virus type 1 infection of human embryonic lung cells. Underglycosylated forms, including the apparent high-mannose precursor forms of the major glycoproteins, appeared. Monensin inhibited virus-induced cell fusion. Infectious virions produced in the presence of monensin appeared to contain predominantly underglycosylated glycoproteins.

Original languageEnglish (US)
Pages (from-to)56-60
Number of pages5
JournalIntervirology
Volume20
Issue number1
DOIs
StatePublished - 1983

Keywords

  • Cell fusion
  • Glycoprotein synthesis
  • Herpes simplex virus type 1
  • Infectious virus
  • Monensin

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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