Effect of testosterone replacement therapy on prostate tissue in men with late-onset hypogonadism

A randomized controlled trial

Leonard S. Marks, Norman A. Mazer, Elahe Mostaghel, David L. Hess, Frederick J. Dorey, Jonathan Ira Epstein, Robert W. Veltri, Danil V. Makarov, Alan Wayne Partin, David G. Bostwick, Maria Luz Macairan, Peter S. Nelson

Research output: Contribution to journalArticle

Abstract

Context: Prostate safety is a primary concern when aging men receive testosterone replacement therapy (TRT), but little information is available regarding the effects of TRT on prostate tissue in men. Objective: To determine the effects of TRT on prostate tissue of aging men with low serum testosterone levels. Design, Setting, and Participants: Randomized, double-blind, placebo-controlled trial of 44 men, aged 44 to 78 years, with screening serum testosterone levels lower than 300 ng/dL (

Original languageEnglish (US)
Pages (from-to)2351-2361
Number of pages11
JournalJournal of the American Medical Association
Volume296
Issue number19
DOIs
StatePublished - Nov 15 2006

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Hypogonadism
Testosterone
Prostate
Randomized Controlled Trials
Therapeutics
Serum
Placebos
Safety

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Effect of testosterone replacement therapy on prostate tissue in men with late-onset hypogonadism : A randomized controlled trial. / Marks, Leonard S.; Mazer, Norman A.; Mostaghel, Elahe; Hess, David L.; Dorey, Frederick J.; Epstein, Jonathan Ira; Veltri, Robert W.; Makarov, Danil V.; Partin, Alan Wayne; Bostwick, David G.; Macairan, Maria Luz; Nelson, Peter S.

In: Journal of the American Medical Association, Vol. 296, No. 19, 15.11.2006, p. 2351-2361.

Research output: Contribution to journalArticle

Marks, LS, Mazer, NA, Mostaghel, E, Hess, DL, Dorey, FJ, Epstein, JI, Veltri, RW, Makarov, DV, Partin, AW, Bostwick, DG, Macairan, ML & Nelson, PS 2006, 'Effect of testosterone replacement therapy on prostate tissue in men with late-onset hypogonadism: A randomized controlled trial', Journal of the American Medical Association, vol. 296, no. 19, pp. 2351-2361. https://doi.org/10.1001/jama.296.19.2351
Marks, Leonard S. ; Mazer, Norman A. ; Mostaghel, Elahe ; Hess, David L. ; Dorey, Frederick J. ; Epstein, Jonathan Ira ; Veltri, Robert W. ; Makarov, Danil V. ; Partin, Alan Wayne ; Bostwick, David G. ; Macairan, Maria Luz ; Nelson, Peter S. / Effect of testosterone replacement therapy on prostate tissue in men with late-onset hypogonadism : A randomized controlled trial. In: Journal of the American Medical Association. 2006 ; Vol. 296, No. 19. pp. 2351-2361.
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