@article{e747fc9b2fe94a609fcf892aa9e94fe5,
title = "Effect of testosterone administration on rates of ethanol elimination in hypogonadal patients",
abstract = "Rates of ethanol elimination were determined in four hypogonadal subjects at one week and again at eight weeks after the administration of one dose of 200 mg of testosterone cypionate (Depo-testosterone). Ethanol elimination was unchanged in two patients, slightly decreased in one, and markedly increased in one patient at eight weeks as compared to one week after testosterone administration. In the three patients with little or no change in ethanol elimination, initial high levels of plasma-free testosterone, ranging from 445.0 to 3.8 ng/dl did not decrease to abnormally low levels, but ranged between 1.6 and 7.7 ng/dl (normal, 1.20-2.10 ng/dl). In the fourth patient, an increase in ethanol elimination from 86.6 to 107.4 mg/kg body weight/hr was associated with a decrease in plasma-free testosterone from a high level of 4.7 to 0.8 ng/dl. These results indicate that pharmacological plasma concentration of testosterone do not affect the rate of ethanol elimination. A suppressing effect of testosterone on rate of ethanol elimination may occur at levels of plasma-free testosterone which extend from abnormally low up into the normal physiologic range.",
keywords = "Ethanol elimination, Hypogonadism, Testosterone",
author = "Esteban Mezey and Bruce Hamilton and Potter, {James J.}",
note = "Funding Information: therapy were studied. Two of the patients had Klinefelter's syndrome, while the other two had primary hypogonadism. The age of the patients ranged from 34 to 65 years (mean = 49 years). Patients with alcoholism, cardiac, hepatic or renal dysfunction were excluded from the study by history, physical examination, and laboratory tests (serum bilirubin, serum aminotransferases, albumin, prothrombin time, and serum creatinine). All patients had a normal body weight and were well-nourished. Only one patient ingested alcoholic beverages on the average of two drinks per week. None of the subjects smoked cigarettes. Two patients had essential hypertension controlled by propranolol and hydrochlorothiazide in one, and by the combination of triamterine and hydrochlorothiazide (Dyazide) in the other one. The study was approved by the Human Volunteers Research Committee of the University of Maryland School of Medicine (responsible for clinical research at the Veterans Administration Medical Center) and by the Institutional Review Board of the Johns Hopkins Medical Institutions. The subjects signed the ~This work was supported by NIAAA Grant AA0626, and by the Veterans Administration. 2Requests for reprints should be addressed to Esteban Mezey, M.D., Hunterian 415, The Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205.",
year = "1989",
doi = "10.1016/0741-8329(89)90092-X",
language = "English (US)",
volume = "6",
pages = "331--333",
journal = "Alcohol",
issn = "0741-8329",
publisher = "Elsevier Inc.",
number = "4",
}