Effect of temperature on cystic fibrosis lung disease and infections

A replicated cohort study

Michael Collaco, John McGready, Deanna M. Green, Kathleen M. Naughton, Christopher P. Watson, Timothy M Shields, Scott C. Bell, Claire E. Wainwright, Garry R Cutting

Research output: Contribution to journalArticle

Abstract

Background: Progressive lung disease accounts for the majority of morbidity and mortality observed in cystic fibrosis (CF). Beyond secondhand smoke exposure and socio-economic status, the effect of specific environmental factors on CF lung function is largely unknown. Methods: Multivariate regression was used to assess correlation between specific environmental factors, the presence of pulmonary pathogens, and variation in lung function using subjects enrolled in the U.S. CF Twin and Sibling Study (CFTSS: n = 1378). Significant associations were tested for replication in the U.S. CF Foundation Patient Registry (CFF: n = 16439), the Australian CF Data Registry (ACFDR: n = 1801), and prospectively ascertained subjects from Australia/New Zealand (ACFBAL: n = 167). Results: In CFTSS subjects, the presence of Pseudomonas aeruginosa (OR = 1.06 per °F; p

Original languageEnglish (US)
Article numbere27784
JournalPLoS One
Volume6
Issue number11
DOIs
StatePublished - Nov 18 2011

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Pulmonary diseases
cystic fibrosis
cohort studies
Cystic Fibrosis
respiratory tract diseases
Lung Diseases
Cohort Studies
Temperature
Pathogens
Infection
Smoke
infection
lung function
temperature
Lung
Registries
Economics
Tobacco Smoke Pollution
Twin Studies
environmental factors

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Effect of temperature on cystic fibrosis lung disease and infections : A replicated cohort study. / Collaco, Michael; McGready, John; Green, Deanna M.; Naughton, Kathleen M.; Watson, Christopher P.; Shields, Timothy M; Bell, Scott C.; Wainwright, Claire E.; Cutting, Garry R.

In: PLoS One, Vol. 6, No. 11, e27784, 18.11.2011.

Research output: Contribution to journalArticle

Collaco, Michael ; McGready, John ; Green, Deanna M. ; Naughton, Kathleen M. ; Watson, Christopher P. ; Shields, Timothy M ; Bell, Scott C. ; Wainwright, Claire E. ; Cutting, Garry R. / Effect of temperature on cystic fibrosis lung disease and infections : A replicated cohort study. In: PLoS One. 2011 ; Vol. 6, No. 11.
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