Effect of systemic hyperandrogenism on the adrenal response to adrenocorticotropin hormone

E. Katz; W. J. Scherzer; R. J. Mansfield; E. Y. Adashi

doi:10.1016/S0015-0282(16)56598-4

Effect of systemic hyperandrogenism on the adrenal response to adrenocorticotropin hormone

E. Katz, W. J. Scherzer, R. J. Mansfield, E. Y. Adashi

Research output: Contribution to journal › Article › peer-review

Abstract

A virilized patient with an androgen-producing ovarian tumor was used to illustrate the effect of chronic hyperandrogenism on the adrenal response to ACTH. The accumulation rates of substrates for 3β-ol dehydrogenase, 21- hydroxylase, and 11β-hydroxylase remained unchanged after oophorectomy. This suggests that chronic hyperandrogenism does not affect the activity of enzymes involved in adrenal steroidogenesis.

Original language	English (US)
Pages (from-to)	567-569
Number of pages	3
Journal	Fertility and sterility
Volume	61
Issue number	3
DOIs	https://doi.org/10.1016/S0015-0282(16)56598-4
State	Published - 1994
Externally published	Yes

Keywords

Adrenocorticotropin stimulation test
adrenal steroidogenesis
hyperandrogenemia
late-onset adrenal hyperplasia

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

Access to Document

10.1016/S0015-0282(16)56598-4

Cite this

@article{9432ec1bd81b46c687e0d1b6761be0a2,

title = "Effect of systemic hyperandrogenism on the adrenal response to adrenocorticotropin hormone",

abstract = "A virilized patient with an androgen-producing ovarian tumor was used to illustrate the effect of chronic hyperandrogenism on the adrenal response to ACTH. The accumulation rates of substrates for 3β-ol dehydrogenase, 21- hydroxylase, and 11β-hydroxylase remained unchanged after oophorectomy. This suggests that chronic hyperandrogenism does not affect the activity of enzymes involved in adrenal steroidogenesis.",

keywords = "Adrenocorticotropin stimulation test, adrenal steroidogenesis, hyperandrogenemia, late-onset adrenal hyperplasia",

author = "E. Katz and Scherzer, {W. J.} and Mansfield, {R. J.} and Adashi, {E. Y.}",

year = "1994",

doi = "10.1016/S0015-0282(16)56598-4",

language = "English (US)",

volume = "61",

pages = "567--569",

journal = "Fertility and sterility",

issn = "0015-0282",

publisher = "Elsevier Inc.",

number = "3",

}

TY - JOUR

T1 - Effect of systemic hyperandrogenism on the adrenal response to adrenocorticotropin hormone

AU - Katz, E.

AU - Scherzer, W. J.

AU - Mansfield, R. J.

AU - Adashi, E. Y.

PY - 1994

Y1 - 1994

N2 - A virilized patient with an androgen-producing ovarian tumor was used to illustrate the effect of chronic hyperandrogenism on the adrenal response to ACTH. The accumulation rates of substrates for 3β-ol dehydrogenase, 21- hydroxylase, and 11β-hydroxylase remained unchanged after oophorectomy. This suggests that chronic hyperandrogenism does not affect the activity of enzymes involved in adrenal steroidogenesis.

AB - A virilized patient with an androgen-producing ovarian tumor was used to illustrate the effect of chronic hyperandrogenism on the adrenal response to ACTH. The accumulation rates of substrates for 3β-ol dehydrogenase, 21- hydroxylase, and 11β-hydroxylase remained unchanged after oophorectomy. This suggests that chronic hyperandrogenism does not affect the activity of enzymes involved in adrenal steroidogenesis.

KW - Adrenocorticotropin stimulation test

KW - adrenal steroidogenesis

KW - hyperandrogenemia

KW - late-onset adrenal hyperplasia

UR - http://www.scopus.com/inward/record.url?scp=0028326394&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028326394&partnerID=8YFLogxK

U2 - 10.1016/S0015-0282(16)56598-4

DO - 10.1016/S0015-0282(16)56598-4

M3 - Article

C2 - 8137989

AN - SCOPUS:0028326394

SN - 0015-0282

VL - 61

SP - 567

EP - 569

JO - Fertility and sterility

JF - Fertility and sterility

IS - 3

ER -

Effect of systemic hyperandrogenism on the adrenal response to adrenocorticotropin hormone

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this