A virilized patient with an androgen-producing ovarian tumor was used to illustrate the effect of chronic hyperandrogenism on the adrenal response to ACTH. The accumulation rates of substrates for 3β-ol dehydrogenase, 21- hydroxylase, and 11β-hydroxylase remained unchanged after oophorectomy. This suggests that chronic hyperandrogenism does not affect the activity of enzymes involved in adrenal steroidogenesis.
- Adrenocorticotropin stimulation test
- adrenal steroidogenesis
- late-onset adrenal hyperplasia
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynecology