Effect of sympathetic reinnervation on cardiac performance after heart transplantation

Frank M. Bengel, Peter Ueberfuhr, Nina Schiepel, Stephan G. Nekolla, Bruno Reichart, Markus Schwaiger

Research output: Contribution to journalArticle

Abstract

Background: Late after cardiac transplantation, limited reinnervation of the transplanted heart may occur, but little is known about the effect of reinnervation on cardiac function and exercise performance. Methods: We quantified the extent of myocardial reinnervation noninvasively in 29 cardiac-transplant recipients, using positron-emission tomography and the catecholamine analogue [11C]hydroxyephedrine. Global and regional ventricular function at rest and during standardized exercise testing was measured with the use of radionuclide angiography, and the results were compared with those in 10 healthy controls. Results: Sympathetic reinnervation, mainly in the anteroseptal wall, was present in 16 of the 29 transplant recipients. At rest, hemodynamic differences were not observed between the patients with reinnervation and those with denervation. However, the latter group had a shorter mean (±SD) exercise time (6.1±1.5 minutes, vs. 8.2±1.2 in the group with reinnervation; P

Original languageEnglish (US)
Pages (from-to)731-738
Number of pages8
JournalNew England Journal of Medicine
Volume345
Issue number10
DOIs
StatePublished - Sep 6 2001
Externally publishedYes

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Heart Transplantation
Exercise
Radionuclide Angiography
Ventricular Function
Denervation
Positron-Emission Tomography
Catecholamines
Hemodynamics
Transplant Recipients

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bengel, F. M., Ueberfuhr, P., Schiepel, N., Nekolla, S. G., Reichart, B., & Schwaiger, M. (2001). Effect of sympathetic reinnervation on cardiac performance after heart transplantation. New England Journal of Medicine, 345(10), 731-738. https://doi.org/10.1056/NEJMoa010519

Effect of sympathetic reinnervation on cardiac performance after heart transplantation. / Bengel, Frank M.; Ueberfuhr, Peter; Schiepel, Nina; Nekolla, Stephan G.; Reichart, Bruno; Schwaiger, Markus.

In: New England Journal of Medicine, Vol. 345, No. 10, 06.09.2001, p. 731-738.

Research output: Contribution to journalArticle

Bengel, FM, Ueberfuhr, P, Schiepel, N, Nekolla, SG, Reichart, B & Schwaiger, M 2001, 'Effect of sympathetic reinnervation on cardiac performance after heart transplantation', New England Journal of Medicine, vol. 345, no. 10, pp. 731-738. https://doi.org/10.1056/NEJMoa010519
Bengel FM, Ueberfuhr P, Schiepel N, Nekolla SG, Reichart B, Schwaiger M. Effect of sympathetic reinnervation on cardiac performance after heart transplantation. New England Journal of Medicine. 2001 Sep 6;345(10):731-738. https://doi.org/10.1056/NEJMoa010519
Bengel, Frank M. ; Ueberfuhr, Peter ; Schiepel, Nina ; Nekolla, Stephan G. ; Reichart, Bruno ; Schwaiger, Markus. / Effect of sympathetic reinnervation on cardiac performance after heart transplantation. In: New England Journal of Medicine. 2001 ; Vol. 345, No. 10. pp. 731-738.
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